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Drug-induced secondary haemophagocytic lymphohistiocytosis in hairy cell leukaemia.
Stark, Katherine; Rowe, Cormac; Mathur, Abhinav; Matossian, James; Lawrie, Alastair.
Afiliación
  • Stark K; Department of Haematology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK.
  • Rowe C; Department of Haematology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK.
  • Mathur A; Department of Haematology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK.
  • Matossian J; Department of Pathology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK.
  • Lawrie A; Department of Haematology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK.
J R Coll Physicians Edinb ; 54(1): 29-33, 2024 03.
Article en En | MEDLINE | ID: mdl-38160201
ABSTRACT
Haemophagocytic lymphohistiocytosis (HLH) is a rare, aggressive, excess immune activation syndrome. Diagnosis can be challenging due to its several clinical mimics including sepsis. There are multiple aetiologies of HLH; in adults, it is most commonly triggered by infection, malignancy, drugs and autoimmune processes. Failure to rapidly diagnose and treat this condition can be fatal. The management of HLH includes identifying and removing the trigger, supportive management and immunosuppression. Identifying the trigger is essential to inform the most appropriate type of immunosuppression. Here, we report a case of likely drug-induced HLH in a patient recently treated for hairy cell leukaemia. The culprit drug was thought to be co-trimoxazole and this case report highlights a very rare complication of this commonly used drug. We discuss our management approach with steroid monotherapy and withdrawal of co-trimoxazole.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia de Células Pilosas / Sepsis / Linfohistiocitosis Hemofagocítica / Neoplasias Límite: Humans / Male / Middle aged Idioma: En Revista: J R Coll Physicians Edinb Asunto de la revista: EDUCACAO / HISTORIA DA MEDICINA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia de Células Pilosas / Sepsis / Linfohistiocitosis Hemofagocítica / Neoplasias Límite: Humans / Male / Middle aged Idioma: En Revista: J R Coll Physicians Edinb Asunto de la revista: EDUCACAO / HISTORIA DA MEDICINA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido