Your browser doesn't support javascript.
loading
Weight-Reducing Dietary Intervention Increases the Ability of Hyperinsulinemia to Suppress Serum Ghrelin Concentration in Individuals with Obesity.
Karczewska-Kupczewska, Monika; Stefanowicz, Magdalena; Nikolajuk, Agnieszka; Straczkowski, Marek.
Afiliación
  • Karczewska-Kupczewska M; Department of Internal Medicine and Metabolic Diseases, Medical University of Bialystok, Poland. Electronic address: monika3101@wp.pl.
  • Stefanowicz M; Department of Metabolic Diseases, Medical University of Bialystok, Poland.
  • Nikolajuk A; Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
  • Straczkowski M; Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
J Nutr ; 154(5): 1631-1639, 2024 05.
Article en En | MEDLINE | ID: mdl-38159811
ABSTRACT

BACKGROUND:

Ghrelin is an orexigenic peptide secreted mainly by the stomach. Serum ghrelin concentrations are suppressed after a meal, probably due to insulin release. Individuals with obesity are characterized by a lower fasting serum ghrelin and a lower ghrelin decrease after a meal. The effect of weight loss on the ability of insulin to suppress serum ghrelin concentration remains unknown.

OBJECTIVE:

The aim of the present study was to analyze the effect of weight-reducing dietary intervention on the ability of hyperinsulinemia to suppress serum ghrelin concentration in young individuals with uncomplicated obesity.

METHODS:

We examined 38 individuals with marked overweight or obesity, who underwent a 12-wk dietary intervention program. Serum ghrelin concentration was measured before and after a 2-h hyperinsulinemic-euglycemic clamp, both pre- and post-intervention. Twenty normal-weight individuals served as a control group and were examined at baseline only.

RESULTS:

Individuals with overweight/obesity were characterized by a lower fasting serum ghrelin concentration than normal-weight individuals (P = 0.006). Insulin decreased serum ghrelin concentration in both groups (P < 0.001); however, this decrease was markedly lower in individuals with overweight/obesity than in normal-weight individuals (99.70 ± 136.37 vs. 215.45 ± 250.28 pg/mL; P = 0.026). Fasting serum ghrelin concentration increased after the intervention. After weight-reducing dietary intervention, the decrease in serum ghrelin concentration after the clamp was significantly greater than the pre-intervention value (99.70 ± 136.37 vs. 221.82 ± 228.75 pg/mL; P = 0.002).

CONCLUSIONS:

Weight-reducing dietary intervention restores the ability of hyperinsulinemia to suppress serum ghrelin concentration. It may suggest an enhanced feeling of satiety after moderate weight loss in individuals with overweight/obesity.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pérdida de Peso / Dieta Reductora / Ghrelina / Hiperinsulinismo / Insulina / Obesidad Límite: Adult / Female / Humans / Male Idioma: En Revista: J Nutr Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pérdida de Peso / Dieta Reductora / Ghrelina / Hiperinsulinismo / Insulina / Obesidad Límite: Adult / Female / Humans / Male Idioma: En Revista: J Nutr Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos