[Autoimmune polyendocrine syndrome in adults. Focus on rheumatological aspects of the problem: A review].
Ter Arkh
; 95(10): 881-887, 2023 Nov 23.
Article
en Ru
| MEDLINE
| ID: mdl-38159022
ABSTRACT
Autoimmune polyglandular syndromes (APS) are a heterogeneous group of clinical conditions characterized by functional impairment of multiple endocrine glands due to loss of central or peripheral immune tolerance. These syndromes are also often accompanied by autoimmune damage to non-endocrine organs. Taking into account the wide range of components and variants of the disease, APS is usually divided into a rare juvenile type (APS 1) and a more common adult type (APS 2-4). APS type 1 is caused by a monogenic mutation, while APS types 2-4 have a polygenic mode of inheritance. One subtype of adult APS (APS 3D) is characterized by a combination of autoimmune thyroid disease and autoimmune rheumatic disease. This review considers the available literature data on combinations that meet the above criteria. Many studies have noted a significantly higher prevalence of rheumatic diseases in patients with autoimmune thyroid disease compared with the control group. Also, as in a number of rheumatic diseases, a more frequent occurrence of autoimmune thyroiditis, primary hypothyroidism and Graves' disease was noted.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
/
Enfermedad de Graves
/
Enfermedades Reumáticas
/
Poliendocrinopatías Autoinmunes
Límite:
Adult
/
Humans
Idioma:
Ru
Revista:
Ter Arkh
Año:
2023
Tipo del documento:
Article
Pais de publicación:
Rusia