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The potential role of Epstein-Barr Virus in breast cancer development.
Gouadfel, Kahina; Khenchouche, Abdelhalim; Rabea, Sameh; Mansour, Ahd A; Salem-Bekhit, Mounir M; Ouhida, Soraya; Msela, Amine; Salem, Mohamed M; Erto, Alessandro; Benguerba, Yacine; Houali, Karim.
Afiliación
  • Gouadfel K; Laboratoire LABAB. Université Mouloud Mammeri de Tizi-Ouzou, Algeria. khkbiochimie@hotmail.fr.
  • Khenchouche A; Département de microbiologie, Faculté des sciences de la nature et de la vie, Université F.A. Sétif 1, Algeria. halim.khenchouche@gmail.com.
  • Rabea S; Department of Pharmaceutical Sciences. College of Pharmacy. AlMAAREFA University, Diriyah 13713 Riyadh, Saudi Arabia. houalitizi@yahoo.fr.
  • Mansour AA; Medical Laboratory Science Department, Fakeeh College for Medical Sciences, P.O. Box 2537, Jeddah 21461, Saudi Arabia. houalitizi@yahoo.fr.
  • Salem-Bekhit MM; Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia. mbekhet@ksu.edu.sa.
  • Ouhida S; Laboratoire d'Anatomie pathologie. CHU Saadna Abdenour, Sétif, Algeria. sorayaouh@yahoo.fr.
  • Msela A; Laboratoire LABAB. Université Mouloud Mammeri de Tizi-Ouzou, Algeria. vet915@gmail.com.
  • Salem MM; Faculty of Medicine, Huazhong University of Science and Technology, Wuhan, China. medozcockney@gmail.com.
  • Erto A; Dipartiment odi Ingegneria Chimica, dei Materialie della Produzione Industriale,Università degli Studidi Napoli FedericoII, P.leTecchio, 80,80125 Napoli, Italy. aleserto@unina.it.
  • Benguerba Y; Laboratoire de Biopharmacie Et Pharmacotechnie (LPBT), Ferhat Abbas Setif 1 University, Setif, Algeria. benguerbayacine@yahoo.fr.
  • Houali K; Laboratoire LABAB. Université Mouloud Mammeri de Tizi-Ouzou, Algeria. houalitizi@yahoo.fr.
Cell Mol Biol (Noisy-le-grand) ; 69(13): 241-249, 2023 Dec 10.
Article en En | MEDLINE | ID: mdl-38158663
ABSTRACT
We are looking into viral components that may contribute to breast cancer in order to find possible therapeutic targets. The Epstein-Barr virus (EBV), which has been found to cause nasopharyngeal carcinoma and Burkitt lymphoma, is thought to play a role in breast cancer. Our series' patients had a median age of 49, with nearly half being under the age of 49. T2 tumors (two to five centimeters in size) make up the vast majority of our collection (60%). Six percent of our patients showed lymph node involvement, with roughly the same number in the N1 and N2 stages (41.17% each). Only 17.64% of people are at the N3 stage. SBR II tumors were the most common (90%). Only 20% of patients have HER2 overexpression, whereas 73.33% have ER expression. EBV was found in 23.33% of breast carcinomas (7 cases/30) after oncoprotein LMP1 expression, but normal surrounding tissues tested negative. We discovered that overexpression of the HER2 protein is inversely related to the two HRs' expression. They have no relationship with EBV infection and, consequently, LMP1 expression. LMP1 expression was not shown to be linked with patient age, tumor grade, tumor size, or lymph node invasion.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias Nasofaríngeas / Infecciones por Virus de Epstein-Barr Límite: Female / Humans Idioma: En Revista: Cell Mol Biol (Noisy-le-grand) Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: Argelia Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias Nasofaríngeas / Infecciones por Virus de Epstein-Barr Límite: Female / Humans Idioma: En Revista: Cell Mol Biol (Noisy-le-grand) Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: Argelia Pais de publicación: Francia