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Association between vitamin D receptor gene FokI polymorphism and mortality in patients with sepsis.
Bozgul, Sukriye Miray Kilincer; Emecen, Durdugul Ayyildiz; Akarca, Funda Karbek; Bozkurt, Devrim; Aydin, Ozgur; Koca, Didem; Can, Ozge; Unalp, Omer Vedat; Atik, Tahir.
Afiliación
  • Bozgul SMK; Faculty of Medicine, Department of Internal Medicine, Ege University, Izmir, Turkey.
  • Emecen DA; Faculty of Medicine, Department of Pediatrics, Division of Pediatric Genetics, Ege University, Izmir, Turkey.
  • Akarca FK; Faculty of Medicine, Department of Emergency Medicine, Ege University, 35100, Bornova, Izmir, Turkey. fundakarbek@gmail.com.
  • Bozkurt D; Faculty of Medicine, Department of Internal Medicine, Ege University, Izmir, Turkey.
  • Aydin O; Faculty of Medicine, Department of Internal Medicine, Ege University, Izmir, Turkey.
  • Koca D; Faculty of Medicine, Department of Internal Medicine, Ege University, Izmir, Turkey.
  • Can O; Faculty of Medicine, Department of Emergency Medicine, Ege University, 35100, Bornova, Izmir, Turkey.
  • Unalp OV; Department of General Surgeon, KTO Karatay University, Konya, Turkey.
  • Atik T; Faculty of Medicine, Department of Pediatrics, Division of Pediatric Genetics, Ege University, Izmir, Turkey.
Mol Biol Rep ; 51(1): 44, 2023 Dec 29.
Article en En | MEDLINE | ID: mdl-38158430
ABSTRACT

BACKGROUND:

Sepsis is life-threatening organ dysfunction as a result of the host's dysregulated immune response to infection. The vitamin D receptor (VDR) gene FokI polymorphism influences immune cell behavior. In the present study, we aimed to investigate the association between VDR FokI polymorphism and mortality in sepsis and non-sepsis patients in the intensive care unit (ICU). METHODS AND

RESULTS:

This is a prospective observational study involving 96 sepsis and 96 non-sepsis patients admitted to the Ege University ICU. VDR FokI polymorphisms were investigated, as well as the relationship between the identified polymorphisms and mortality.  In-hospital mortality was 27.1% in the sepsis group and 8.33% in the non-sepsis group (p = 0.001). The frequencies of VDR FokI TT, TC, and CC genotypes were 8 (8.33%), 48 (50.0%), and 40 (41.7%) in the sepsis group, and 11 (11.5%), 42 (43.8%), and 43 (44.8%) in the non-sepsis group, respectively (p = 0.612). In the sepsis group, the frequencies of Fokl TT, TC, and CC genotypes did not differ significantly between survivors and non-survivors. However, homozygous C allele carriers had lower overall mortality (p = 0.047).

CONCLUSION:

The VDR FokI polymorphism, particularly the CC genotype, appears to be associated with lower mortality in ICU patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Calcitriol / Sepsis Límite: Humans Idioma: En Revista: Mol Biol Rep Año: 2023 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Calcitriol / Sepsis Límite: Humans Idioma: En Revista: Mol Biol Rep Año: 2023 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Países Bajos