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Melanocyte transplantation to skin prepared by controlled PUVA-induced sunburn-like blistering for vitiligo treatment - A pilot clinical trial.
Chen, Po-Hua; Mai-Yi Fan, Sabrina; She, Bin-Ru; Wu, Yi-Ping; Hsu, Hsiang-Chun; Yang, Ying-Jung; Huang, Jun-Jae; Yeh, Shu-Fen; Chen, Yi-Chen; Lin, Pei-Ju; Chen, Wann-Hsin; Chiu, Hsien-Ching; Yu, Hsin-Su; Liao, Chih-Ching; Lin, Sung-Jan.
Afiliación
  • Chen PH; Department of Dermatology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
  • Mai-Yi Fan S; Center for Cell Therapy, Department of Biomedical Research, National Taiwan University Hospital, Taipei, Taiwan.
  • She BR; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
  • Wu YP; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
  • Hsu HC; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
  • Yang YJ; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
  • Huang JJ; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
  • Yeh SF; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
  • Chen YC; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
  • Lin PJ; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
  • Chen WH; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
  • Chiu HC; Department of Dermatology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
  • Yu HS; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Liao CC; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan. Electronic address: RitaLiao@itri.org.tw.
  • Lin SJ; Department of Dermatology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan; Department of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan; C
J Formos Med Assoc ; 123(8): 837-842, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38158260
ABSTRACT
Vitiligo is a common acquired disease of pigment loss. In lesions recalcitrant to non-invasive treatment, transplantation of cultured autologous melanocytes is an emerging choice. Conventionally, the recipient site is often prepared by laser-mediated or mechanical dermabrasion. Such preparation procedures have disadvantages including prolonged transplantation duration, long period for reepithelialization and potential scarring. We propose a method of preparing recipient sites by psoralen and controlled ultraviolet A (PUVA)-induced blistering followed by transplanting suspended melanocytes. We introduced this method in 10 patients with segmental vitiligo on their recipient site 3 to 5 days before transplantation and blistering developed in 2 to 3 days afterwards. On the day of transplantation, the blister roof could be peeled off easily without bleeding and the recipient site preparation could be completed in 20 min. The recipient site became reepithelialized within 1 week. Progressive repigmentation was observed for up to 6 months, with an average of 65.06% repigmentation in the recipient site without scarring at the end of follow-up. Hence, preparation of the recipient site by controlled PUVA-induced sunburn-like blistering can potentially facilitate melanocyte transplantation and prevent scarring.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia PUVA / Vitíligo / Melanocitos Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Formos Med Assoc Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Singapur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia PUVA / Vitíligo / Melanocitos Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Formos Med Assoc Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Singapur