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Phytochemical, bactericidal, antioxidant and anti-inflammatory properties of various extracts from Pongamia pinnata and functional groups characterization by FTIR and HPLC analyses.
Al-Ansari, Mysoon; Al-Dahmash, Nora Dahmash; Angulo-Bejarano, Paola Isabel; Ha, Hai-Anh; Nguyen-Thi, Thai-Hang.
Afiliación
  • Al-Ansari M; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
  • Al-Dahmash ND; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
  • Angulo-Bejarano PI; Tecnologico de Monterrey, Centre of Bioengineering, NatProLab, Plant Innovation Lab, School of Engineering and Sciences, Queretaro, 76130, Mexico.
  • Ha HA; Faculty of Pharmacy, Duy Tan University, Da Nang, 550000, Vietnam.
  • Nguyen-Thi TH; Faculty of Pharmacy, Duy Tan University, Da Nang, 550000, Vietnam. Electronic address: thaihang.dtu@gmail.com.
Environ Res ; 245: 118044, 2024 Mar 15.
Article en En | MEDLINE | ID: mdl-38157963
ABSTRACT
The present research looked into possible biomedical applications of Pongamia pinnata leaf extract. The first screening of the phytochemical profile showed that the acetone extract had more phytochemicals than the other solvent extracts. These included more saponins, proteins, phenolic compounds, tannins, glycosides, flavonoids, steroids, and sugar. The P. pinnata acetone extract exhibited highest antibacterial activity against C. diphtheriae. The bactericidal activity was found in the following order C. diphtheria (14 mm) > P. aeruginosa (10 mm) > S. flexneri (9 mm) > S. marcescens (7 mm) > S. typhi (7 mm) > S. epidermidis (7 mm) > S. boydii (6 mm) > S. aureus (3 mm) at 10 mg mL-1 concentration. MIC value of 240 mg mL-1 and MBC is 300 mg mL-1 of concentration with 7 colonies against C. diphtheriae was noticed in acetone extract. Acetone extract of P. pinnata was showed highest percentage of inhibition (87.5 %) at 625 mg mL-1 concentrations by DPPH method. Furthermore, the anti-inflammatory activity showed the fine albumin denaturation as 76% as well as anti-lipoxygenase was found as 61% at 900 mg mL-1 concentrations correspondingly. FT-IR analysis was used to determine the functional groups of compounds with bioactive properties. The qualitative examination of selected plants through HPLC yielded significant peak values determined by intervals through the peak value. In an acetone extract of P. pinnata, 9 functional groups were identified. These findings concluded that the acetone extract has high pharmaceutical value, but more in-vivo research is needed to assess its potential.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Millettia / Antioxidantes Idioma: En Revista: Environ Res Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Millettia / Antioxidantes Idioma: En Revista: Environ Res Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Países Bajos