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Anti-oncogenic Potential and Inflammation Modulatory Response of Green Synthesized Biocompatible Silver Nanoparticles.
Nagarajaiah, Shobha; Shivanna Giresha, Aladahalli; Gopala Krishna, Prashanth; Manikrao Gadewar, Manoj; Praveen, Manjappa; Nanda, Nagappa; Urs, Deepadarshan; Krishnappa Dharmappa, Kattepura; Mutta Nagabhushana, Bhangi; Rao, Srilatha; Mahadeva Swamy, Mallanna; Venkatesh Yatish, Kalanakoppal.
Afiliación
  • Nagarajaiah S; Department of Chemistry, Maharani's Science College for Women, Maharani Cluster University, 560 001, Bengaluru, India.
  • Shivanna Giresha A; Department of Biochemistry, Jain (Deemed-to-be University), School of Science, JC Road, 560 027, Bangalore, India.
  • Gopala Krishna P; Research and Development Center, Department of Chemistry, Sir M. Visvesvaraya Institute of Technology, 562 157, Bengaluru, India.
  • Manikrao Gadewar M; Department of Pharmacology, School of Medical and Allied Sciences, KR Mangalam University, 122 103, Gurgaon, India.
  • Praveen M; Centre for Advanced Materials Technology (CAMT), M.S Ramaiah Institute of Technology, 560 054, Bengaluru, India.
  • Nanda N; Department of Chemistry, BMS College of Engineering, 560 019, Bengaluru, India.
  • Urs D; Inflammation Research Laboratory, Department of Studies and Research in Biochemistry, Mangalore University, Jnana Kaveri Post Graduate Centre, Chikka Aluvara, 571 232, Kodagu, India.
  • Krishnappa Dharmappa K; Inflammation Research Laboratory, Department of Studies and Research in Biochemistry, Mangalore University, Jnana Kaveri Post Graduate Centre, Chikka Aluvara, 571 232, Kodagu, India.
  • Mutta Nagabhushana B; Department of Chemistry, M.S Ramaiah Institute of Technology, 560 054, Bengaluru, India.
  • Rao S; Department of Chemistry, Nitte Meenakshi Institute of Technology, 560 064, Bengaluru, India.
  • Mahadeva Swamy M; Department of PG Chemistry, JSS College of Arts Commerce and Science, 570 025, Mysuru, India.
  • Venkatesh Yatish K; Department of Chemistry, Navkis College of Engineering, 573 217, Hassan, India.
Chem Biodivers ; 21(3): e202301533, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38156969
ABSTRACT
This study presents a novel approach to synthesizing silver nanoparticles (Ag NPs) using a solution combustion synthesis (SCS) method with Catharanthus roseus (C. roseus) leaf extract. The NPs were thoroughly characterized through X-ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive X-ray (EDX), Transmission electron microscopy (TEM), and Selected area electron diffraction (SAED), elucidating their crystal structure. Notably, the synthesized Ag NPs exhibited a significant dose-dependent decline in viability of the MDA-MB 231 breast cancer cell line, with an IC50 value of 13.3 µg/mL, underscoring their potential as potent anticancer agent. Beyond cytotoxicity, the study pioneers an investigation into the biocompatibility of Ag NPs by blood hemolsysis, providing critical insights into their safety and biomedical applicability. Furthermore, this research uncovers a distinctive facet of Ag NPs, revealing their inhibitory effects on the inflammatory enzyme secretory phospholipase A2 (sPLA2), a recognized biomarker for breast cancer. The demonstrated in vitro and in vivo inhibition of sPLA2 highlights the multifaceted potential of Ag NPs in not only targeting cancer cells but also modulating inflammatory responses associated with breast cancer, positioning the study at the forefront of advancements in nanomedicine and cancer therapeutics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Nanopartículas del Metal / Fosfolipasas A2 Secretoras Límite: Female / Humans Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Nanopartículas del Metal / Fosfolipasas A2 Secretoras Límite: Female / Humans Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Suiza