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Lifetime Blast Exposure Is Not Related to White Matter Integrity in Service Members and Veterans With and Without Uncomplicated Mild Traumatic Brain Injury.
Lippa, Sara M; Yeh, Ping-Hong; Kennedy, Jan E; Bailie, Jason M; Ollinger, John; Brickell, Tracey A; French, Louis M; Lange, Rael T.
Afiliación
  • Lippa SM; Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
  • Yeh PH; National Intrepid Center of Excellence, Bethesda, Maryland, USA.
  • Kennedy JE; Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Bailie JM; Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
  • Ollinger J; National Intrepid Center of Excellence, Bethesda, Maryland, USA.
  • Brickell TA; Traumatic Brain Injury Center of Excellence, Silver Spring, Maryland, USA.
  • French LM; Contractor, General Dynamics Information Technology, Silver Spring, Maryland, USA.
  • Lange RT; Brooke Army Medical Center, Joint Base, San Antonio, Texas, USA.
Neurotrauma Rep ; 4(1): 827-837, 2023.
Article en En | MEDLINE | ID: mdl-38156076
ABSTRACT
This study examines the impact of lifetime blast exposure on white matter integrity in service members and veterans (SMVs). Participants were 227 SMVs, including those with a history of mild traumatic brain injury (mTBI; n = 124), orthopedic injury controls (n = 58), and non-injured controls (n = 45), prospectively enrolled in a Defense and Veterans Brain Injury Center (DVBIC)/Traumatic Brain Injury Center of Excellence (TBICoE) study. Participants were divided into three groups based on number of self-reported lifetime blast exposures none (n = 53); low (i.e., 1-9 blasts; n = 81); and high (i.e., ≥10 blasts; n = 93). All participants underwent diffusion tensor imaging (DTI) at least 11 months post-injury. Tract-of-interest (TOI) analysis was applied to investigate fractional anisotropy and mean, radial, and axial diffusivity (AD) in left and right total cerebral white matter as well as 24 tracts. Benjamini-Hochberg false discovery rate (FDR) correction was used. Regressions investigating blast exposure and mTBI on white matter integrity, controlling for age, revealed that the presence of mTBI history was associated with lower AD in the bilateral superior longitudinal fasciculus and arcuate fasciculus and left cingulum (ßs = -0.255 to -0.174; ps < 0.01); however, when non-injured controls were removed from the sample (but orthopedic injury controls remained), these relationships were attenuated and did not survive FDR correction. Regression models were rerun with modified post-traumatic stress disorder (PTSD) diagnosis added as a predictor. After FDR correction, PTSD was not significantly associated with white matter integrity in any of the models. Overall, there was no relationship between white matter integrity and self-reported lifetime blast exposure or PTSD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurotrauma Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurotrauma Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos