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Magnetic susceptibility and R2*-based texture analysis for evaluating liver fibrosis in chronic liver disease.
Guo, Ran; Zhong, Haodong; Xing, Feng; Lu, Fang; Qu, Zheng; Tong, Rui; Gan, Fengling; Liu, Mengxiao; Fu, Caixia; Xu, Huihui; Li, Gaiying; Liu, Chenghai; Li, Jianqi; Yang, Shuohui.
Afiliación
  • Guo R; Department of Radiology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China.
  • Zhong H; Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200062, PR China.
  • Xing F; Department of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
  • Lu F; Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
  • Qu Z; Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200062, PR China.
  • Tong R; Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200062, PR China.
  • Gan F; Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200062, PR China.
  • Liu M; MR Scientific Marketing, Diagnostic Imaging, Siemens Healthineers Ltd, Shanghai 201318, PR China.
  • Fu C; MR Applications Development, Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen 518057, PR China.
  • Xu H; Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
  • Li G; Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200062, PR China.
  • Liu C; Department of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai 201203, PR China.
  • Li J; Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200062, PR China. Electronic address: jqli@phy.ecnu.edu.cn.
  • Yang S; Department of Radiology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China. Electronic address: caddie_yang1980@aliyun.com.
Eur J Radiol ; 169: 111155, 2023 Dec.
Article en En | MEDLINE | ID: mdl-38155592
ABSTRACT

PURPOSE:

To explore potential feasibility of texture features in magnetic susceptibility and R2* maps for evaluating liver fibrosis.

METHODS:

Thirty-one patients (median age 46 years; 22 male) with chronic liver disease were prospectively recruited and underwent magnetic resonance imaging (MRI), blood tests, and liver biopsy. Susceptibility and R2* maps were obtained using a 3-dimensional volumetric interpolated breath-hold examination sequence with a 3T MRI scanner. Texture features, including histogram, gray-level co-occurrence matrix (GLCM), gray-level dependence matrix (GLDM), gray-level run length matrix (GLRLM), gray-level size zone matrix (GLSZM), and neighboring gray tone difference matrix (NGTDM) features, were extracted. Texture features and blood test results of non-significant (Ishak-F < 3) and significant fibrosis patients (Ishak-F ≥ 3) were compared, and correlations with Ishak-F stages were analyzed. Areas under the curve (AUCs) were calculated to determine the efficacy for evaluating liver fibrosis.

RESULTS:

Nine texture features of susceptibility maps and 19 features of R2* maps were significantly different between non-significant and significant fibrosis groups (all P < 0.05). Large dependence high gray-level emphasis (LDHGLE) of GLDM and long run high gray-level emphasis (LRHGLE) of GLRLM in R2* maps showed significantly negative and good correlations with Ishak-F stages (r = -0.616, P < 0.001; r = -0.637, P < 0.001). Busyness (NGTDM) in susceptibility maps, LDHGLE of GLDM and LRHGLE of GLRLM in R2* maps yield the highest AUCs (AUC = 0.786, P = 0.007; AUC = 0.807, P = 0.004; AUC = 0.819, P = 0.003).

CONCLUSION:

Texture characteristics of susceptibility and R2* maps revealed possible staging values for liver fibrosis. Susceptibility and R2*-based texture analysis may be a useful and noninvasive method for staging liver fibrosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Cirrosis Hepática Límite: Humans / Male / Middle aged Idioma: En Revista: Eur J Radiol Año: 2023 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Cirrosis Hepática Límite: Humans / Male / Middle aged Idioma: En Revista: Eur J Radiol Año: 2023 Tipo del documento: Article Pais de publicación: Irlanda