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REVIEW OF THE NATURE OF ANTI/INFLAMMATORY AND PRO-INFLAMMATORY CYTOKINE REGULATION IN DIFFERENT PERIODS OF PLASMA CELL MYELOMA NATURAL HISTORY IN THE CHORNOBYL NPP ACCIDENT SURVIVORS. / АНАЛІЗ ХАРАКТЕРУ РЕГУЛЯЦІЇ ПРОТИЗАПАЛЬНИХ І ПРОЗАПАЛЬНИХ ЦИТОКІНІВ НА РІЗНИХ ЕТАПАХ ПЕРЕБІГУ ПЛАЗМОКЛІТИННОЇ МІЄЛОМИ У ХВОРИХ, ЯКІ ПОСТРАЖДАЛИ ВНАСЛІДОК АВАРІЇ НА ЧОРНОБИЛЬСЬКІЙ АЕС.
Minchenko, Zh M; Dmytrenko, O O; Silaiev, Yu O; Liubarets, T F.
Afiliación
  • Minchenko ZM; State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine¼, 53 Yuriia Illienka St., Kyiv, 04050, Ukraine.
  • Dmytrenko OO; State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine¼, 53 Yuriia Illienka St., Kyiv, 04050, Ukraine.
  • Silaiev YO; State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine¼, 53 Yuriia Illienka St., Kyiv, 04050, Ukraine.
  • Liubarets TF; O.O. Bogomolets National Medical University, 13 Taras Shevchenko Blvd, Kyiv, 01601, Ukraine.
Probl Radiac Med Radiobiol ; 28: 374-386, 2023 Dec.
Article en En, Uk | MEDLINE | ID: mdl-38155134
ABSTRACT

OBJECTIVE:

identify the nature of anti-inflammatory and pro-inflammatory cytokine regulation in different periods of plasma cell myeloma (PCM) natural history with evaluation of its role as a prognostic criterion for the disease course in the Chornobyl NPP (ChNPP) accident survivors. MATERIALS AND

METHODS:

Levels of pro-inflammatory (IL-6, TNF-α) and anti-inflammatory (IL-10) cytokines both with their relationship were studied in the stage I-II and stage III PCM patients (n = 74) in different periods of the disease natural history i.e. remission/stabilization and progression. Study groups included the ChNPP accident survivors (n = 35) and non-irradiated subjects (n = 39). Immunoenzymatic method was applied using the Vector-Best CJSC commercial kits.

RESULTS:

There was a unidirectional increase in the levels of IL-6, TNF-α, and IL-10 in irradiated persons, and an elevation of IL-6 and TNF-α concentration but with a decreased level of IL-10 in non-irradiated subjects compared to control at the time of PCM diagnosis. Period of the disease remission/stabilization in PCM stage I-II patients featured a decrease in IL-6 concentration regardless of the exposure to ionizing radiation, while TNF-α content remained at the level of the control group. There was a significant increase in IL-6 concentration in both study groups during the disease relapse, while TNF-α level remained unchanged compared to stabilization phase of the disease. According to the obtained data a certain contribution of radiation exposure to the PCM pathogenesis as a possible predictor of the exacerbated disease course cannon be excluded.

CONCLUSION:

Determining the serum level of pro-inflammatory and anti-inflammatory cytokines (IL-6, TNF-α and IL-10 respectively) provides advancement in assessment of the PCM course and predict the effectiveness of administration of therapy protocols.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Nuclear de Chernóbil / Mieloma Múltiple Límite: Humans Idioma: En / Uk Revista: Probl Radiac Med Radiobiol Año: 2023 Tipo del documento: Article País de afiliación: Ucrania Pais de publicación: Ucrania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Nuclear de Chernóbil / Mieloma Múltiple Límite: Humans Idioma: En / Uk Revista: Probl Radiac Med Radiobiol Año: 2023 Tipo del documento: Article País de afiliación: Ucrania Pais de publicación: Ucrania