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Effects of azithromycin exposure during pregnancy at different stages, doses and courses on testicular development in fetal mice.
Kong, Ziyu; Zhu, Lu; Liu, Yi; Liu, Yi; Chen, Guanghui; Jiang, Tao; Wang, Hui.
Afiliación
  • Kong Z; Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China.
  • Zhu L; Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China.
  • Liu Y; Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China.
  • Liu Y; Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
  • Chen G; Wuhan University People's Hospital, Wuhan 430071, China.
  • Jiang T; Suizhou Emergency Medical Center, Suizhou 441300, China. Electronic address: 2215460015@qq.com.
  • Wang H; Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address: wanghui19@whu.edu.cn.
Biomed Pharmacother ; 170: 116063, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38154271
ABSTRACT
Azithromycin is a commonly used antibiotic during pregnancy, but some studies have suggested its potential developmental toxicity. Currently, the effects and mechanisms of prenatal azithromycin exposure (PAzE) on fetal testicular development are still unclear. The effects of prenatal exposure to the same drug on fetal testicular development could vary depending on different stages, doses, and courses. Hence, in this study, based on clinical medication characteristics, Kunming mice was administered intragastrically with azithromycin at different stages (mid-/late-pregnancy), doses (50, 100, 200 mg/kg·d), and courses (single-/multi-course). Fetal blood and testicular samples were collected on GD18 for relevant assessments. The results indicated that PAzE led to changes in fetal testicular morphology, reduced cell proliferation, increased apoptosis, and decreased expression of markers related to Leydig cells (Star), Sertoli cells (Wt1), and spermatogonia (Plzf). Further investigation revealed that the effects of PAzE on fetal testicular development were characterized by mid-pregnancy, high dose (clinical dose), and single course having more pronounced effects. Additionally, the TGFß/Smad and Nrf2 signaling pathways may be involved in the changes in fetal testicular development induced by PAzE. In summary, this study confirmed that PAzE influences fetal testicular morphological development and multicellular function. It provided theoretical and experimental evidence for guiding the rational use of azithromycin during pregnancy and further exploring the mechanisms underlying its developmental toxicity on fetal testicles.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testículo / Azitromicina Límite: Animals / Pregnancy Idioma: En Revista: Biomed Pharmacother Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testículo / Azitromicina Límite: Animals / Pregnancy Idioma: En Revista: Biomed Pharmacother Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia