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The Role of Regulatory Cell Death in Vitiligo.
Liu, Lyu-Ye; He, Si-Jia; Chen, Zhao; Ge, Man; Lyu, Chun-Yi; Gao, Dandan; Yu, Ji-Peng; Cai, Meng-Han; Yuan, Jin-Xiang; Zhang, Jun-Ling.
Afiliación
  • Liu LY; Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
  • He SJ; Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, People's Republic of China.
  • Chen Z; First Clinical Medical College Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China.
  • Ge M; Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
  • Lyu CY; First Clinical Medical College Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China.
  • Gao D; Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
  • Yu JP; Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
  • Cai MH; Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
  • Yuan JX; Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
  • Zhang JL; Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, People's Republic of China.
DNA Cell Biol ; 43(2): 61-73, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38153369
ABSTRACT
Vitiligo is one of the common chronic autoimmune skin diseases in clinic, which is characterized by localized or generalized depigmentation and seriously affects the physical and mental health of patients. At present, the pathogenesis of vitiligo is not clear; mainly, heredity, autoimmunity, oxidative stress, melanocyte (MC) self-destruction, and the destruction, death, or dysfunction of MCs caused by various reasons are always the core of vitiligo. Regulatory cell death (RCD) is an active and orderly death mode of cells regulated by genes, which widely exists in various life activities, plays a pivotal role in maintaining the homeostasis of the organism, and is closely related to the occurrence and development of many diseases. With the deepening of the research and understanding of RCD, people gradually found that there are many different forms of RCD in the lesions and perilesional skin of vitiligo patients, such as apoptosis, autophagy, pyroptosis, ferroptosis, and so on. Different cell death modes have different mechanisms in vitiligo, and different RCDs can interact and regulate each other. In this article, the mechanism related to RCD in the pathogenesis of vitiligo is reviewed, which provides new ideas for exploring the pathogenesis and targeted treatment of vitiligo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitíligo Límite: Humans Idioma: En Revista: DNA Cell Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitíligo Límite: Humans Idioma: En Revista: DNA Cell Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos