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The Cerebellum and Cognitive Function: Anatomical Evidence from a Transdiagnostic Sample.
Bègue, Indrit; Elandaloussi, Yannis; Delavari, Farnaz; Cao, Hengyi; Moussa-Tooks, Alexandra; Roser, Mathilde; Coupé, Pierrick; Leboyer, Marion; Kaiser, Stefan; Houenou, Josselin; Brady, Roscoe; Laidi, Charles.
Afiliación
  • Bègue I; Department of Psychiatry, Beth Israel Deaconess Medical School & Harvard Medical School, Boston, MA, USA. indrit.begue@unige.ch.
  • Elandaloussi Y; Department of Psychiatry, McLean Hospital & Harvard Medical School, Boston, MA, USA. indrit.begue@unige.ch.
  • Delavari F; Department of Psychiatry, University Hospitals of Geneva & University of Geneva, Geneva, Switzerland. indrit.begue@unige.ch.
  • Cao H; INSERM U955, Institut Mondor de La Recherche Biomédicale (IRMB), Univ. Paris Est Créteil, Equipe 15 Neuropsychiatrie Translationnelle, Créteil, France.
  • Moussa-Tooks A; La Fondation Fondamental, Créteil, France.
  • Roser M; NeuroSpin, Neuroimaging Platform, CEA, UNIACT Lab, PsyBrain Team, Saclay, France.
  • Coupé P; Developmental Imaging and Psychopathology Laboratory, University of Geneva School of Medicine, Geneva, Switzerland.
  • Leboyer M; Neuro-X Institute, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland.
  • Kaiser S; Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA.
  • Houenou J; Division of Psychiatry Research, Zucker Hillside Hospital, Queens, NY, USA.
  • Brady R; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Laidi C; INSERM U955, Institut Mondor de La Recherche Biomédicale (IRMB), Univ. Paris Est Créteil, Equipe 15 Neuropsychiatrie Translationnelle, Créteil, France.
Cerebellum ; 23(4): 1399-1410, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38151675
ABSTRACT
Multiple lines of evidence across human functional, lesion, and animal data point to a cerebellar role, in particular of crus I, crus II, and lobule VIIB, in cognitive function. However, a mapping of distinct facets of cognitive function to cerebellar structure is missing. We analyzed structural neuroimaging data from the Healthy Brain Network (HBN). Cerebellar parcellation was performed with a validated automated segmentation pipeline (CERES) and stringent visual quality check (n = 662 subjects retained from initial n = 1452). Canonical correlation analyses (CCA) examined regional gray matter volumetric (GMV) differences in association to cognitive function (quantified with NIH Toolbox Cognition domain, NIH-TB), accounting for psychopathology severity, age, sex, scan location, and intracranial volume. Multivariate CCA uncovered a significant correlation between two components entailing a latent cognitive canonical (NIH-TB subscales) and a brain canonical variate (cerebellar GMV and intracranial volume, ICV), surviving bootstrapping and permutation procedures. The components correspond to partly shared cerebellar-cognitive function relationship with a first map encompassing cognitive flexibility (r = 0.89), speed of processing (r = 0.65), and working memory (r = 0.52) associated with regional GMV in crus II (r = 0.57) and lobule X (r = 0.59) and a second map including the crus I (r = 0.49) and lobule VI (r = 0.49) associated with working memory (r = 0.51). We show evidence for a structural subspecialization of the cerebellum topography for cognitive function in a transdiagnostic sample.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Cerebelo / Cognición Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cerebellum Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Cerebelo / Cognición Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cerebellum Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos