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Exploring occupational toxicant exposures in patients with metabolic dysfunction-associated steatotic liver disease: A prospective pilot study.
Tovoli, Francesco; Stefanini, Bernardo; Mandrioli, Daniele; Mattioli, Stefano; Vornoli, Andrea; Sgargi, Daria; Manservisi, Fabiana; Piscaglia, Fabio; Curti, Stefania; Bolondi, Luigi.
Afiliación
  • Tovoli F; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. Electronic address: francesco.tovoli@unibo.it.
  • Stefanini B; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
  • Mandrioli D; Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bologna, Italy.
  • Mattioli S; Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.
  • Vornoli A; Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bologna, Italy.
  • Sgargi D; Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bologna, Italy.
  • Manservisi F; Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bologna, Italy.
  • Piscaglia F; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Curti S; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
  • Bolondi L; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Dig Liver Dis ; 56(4): 571-578, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38151451
ABSTRACT

BACKGROUND:

Metabolic dysfunction-associated steatotic liver disease (MASLD) has been traditionally associated with insulin resistance and obesity. Recently, pollutants have been shown to contribute to the development of MASLD. Given the global burden of MASLD, understanding whether pollutants are merely associated with steatosis or contribute to its progression to advanced chronic liver disease (ACLD) and hepatocellular carcinoma (HCC) is critical. Workers exposed to occupational toxicants represent an ideal population for assessing the potentially hazardous consequences of professional exposure. Confirming a link between occupational exposure and ACLD/HCC may not only provide further elements in understanding MASLD, but also contribute to preventive strategies for exposed workers.

OBJECTIVE:

This study aimed to assess the prevalence of self-reported occupational exposure to toxicants in patients with MASLD.

METHODS:

This hospital-based prospective pilot study included 201 patients with MASLD. Data on workplace toxicant exposure were collected systematically using a structured questionnaire. Subsequently, patients with ACLD and/or HCC (n = 55) were compared to controls (n = 146). Logistic regression analysis and propensity score models were used to investigate the associations between self-reported occupational exposure and ACLD and/or HCC.

RESULTS:

Patients with ACLD/HCC reported exposure to metals, halogenated refrigerants, pain/resins, and fuel emissions more often than the controls. After controlling for confounders, durations of 21-30 years and >30 years of occupational exposure to toxicants showed odds ratios (ORs) of 2.31 (95 % confidence interval [CI] 1.09-4.88, p = 0.029) and 4.47 (95 % CI 2.57-7.78, p<0.001), respectively.

CONCLUSIONS:

In this pilot study, patients with MASLD complications were more likely to report workplace toxicant exposure. Our results warrant future multicentre confirmatory studies, as implementing prevention policies may reduce the risk of life-threatening diseases among exposed populations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Exposición Profesional / Carcinoma Hepatocelular / Contaminantes Ambientales / Hígado Graso / Neoplasias Hepáticas / Enfermedades Metabólicas Límite: Humans Idioma: En Revista: Dig Liver Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Exposición Profesional / Carcinoma Hepatocelular / Contaminantes Ambientales / Hígado Graso / Neoplasias Hepáticas / Enfermedades Metabólicas Límite: Humans Idioma: En Revista: Dig Liver Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos