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Intra-individual comparison of coronary CT angiography-based FFR between energy-integrating and photon-counting detector CT systems.
Zsarnoczay, Emese; Pinos, Daniel; Schoepf, U Joseph; Fink, Nicola; O'Doherty, Jim; Gnasso, Chiara; Griffith, Joseph; Vecsey-Nagy, Milán; Suranyi, Pal; Maurovich-Horvat, Pál; Emrich, Tilman; Varga-Szemes, Akos.
Afiliación
  • Zsarnoczay E; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA; MTA-SE Cardiovascular Imaging Research Group, Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary.
  • Pinos D; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA.
  • Schoepf UJ; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA.
  • Fink N; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA; Department of Radiology, University Hospital, LMU Munich, Munich, Germany.
  • O'Doherty J; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA; Siemens Medical Solutions USA Inc, Malvern, USA.
  • Gnasso C; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA; Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Griffith J; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA.
  • Vecsey-Nagy M; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
  • Suranyi P; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA.
  • Maurovich-Horvat P; MTA-SE Cardiovascular Imaging Research Group, Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary.
  • Emrich T; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA; Department of Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany; German Centre for Cardio
  • Varga-Szemes A; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA.
Int J Cardiol ; 399: 131684, 2024 Mar 15.
Article en En | MEDLINE | ID: mdl-38151162
ABSTRACT

BACKGROUND:

Coronary computed tomography angiography (CCTA)-based fractional flow reserve (CT-FFR) allows for noninvasive determination of the functional severity of anatomic lesions in patients with coronary artery disease. The aim of this study was to intra-individually compare CT-FFR between photon-counting detector (PCD) and conventional energy-integrating detector (EID) CT systems.

METHODS:

In this single-center prospective study, subjects who underwent clinically indicated CCTA on an EID-CT system were recruited for a research CCTA on PCD-CT within 30 days. Image reconstruction settings were matched as closely as possible between EID-CT (Bv36 kernel, iterative reconstruction strength level 3, slice thickness 0.5 mm) and PCD-CT (Bv36 kernel, quantum iterative reconstruction level 3, virtual monoenergetic level 55 keV, slice thickness 0.6 mm). CT-FFR was measured semi-automatically using a prototype on-site machine learning algorithm by two readers. CT-FFR analysis was performed per-patient and per-vessel, and a CT-FFR ≤ 0.75 was considered hemodynamically significant.

RESULTS:

A total of 22 patients (63.3 ± 9.2 years; 7 women) were included. Median time between EID-CT and PCD-CT was 5.5 days. Comparison of CT-FFR values showed no significant difference and strong agreement between EID-CT and PCD-CT in the per-vessel analysis (0.88 [0.74-0.94] vs. 0.87 [0.76-0.93], P = 0.096, mean bias 0.02, limits of agreement [LoA] -0.14/0.19, r = 0.83, ICC = 0.92), and in the per-patient analysis (0.81 [0.60-0.86] vs. 0.76 [0.64-0.86], P = 0.768, mean bias 0.02, LoA -0.15/0.19, r = 0.90, ICC = 0.93). All included patients were classified into the same category (CT-FFR > 0.75 vs ≤0.75) with both CT systems.

CONCLUSIONS:

CT-FFR evaluation is feasible with PCD-CT and it shows a strong agreement with EID-CT-based evaluation when images are similarly reconstructed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reserva del Flujo Fraccional Miocárdico / Angiografía por Tomografía Computarizada Límite: Female / Humans Idioma: En Revista: Int J Cardiol Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reserva del Flujo Fraccional Miocárdico / Angiografía por Tomografía Computarizada Límite: Female / Humans Idioma: En Revista: Int J Cardiol Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Países Bajos