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Ventilation Heterogeneity Is a Treatable Trait in Severe Asthma.
Gibson, Peter G; Urroz Guerrero, Paola D; Poon, Christine; Rutherford, Natalie; Brooker, Bree; Smith, Amber; Grainge, Christopher; Wark, Peter A B; McDonald, Vanessa M.
Afiliación
  • Gibson PG; Centre of Excellence in Treatable Traits, College of Health, Medicine and Wellbeing, University of Newcastle, New Lambton Heights, New South Wales, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, New South Wales, Australia. Electronic address: Pete
  • Urroz Guerrero PD; Centre of Excellence in Treatable Traits, College of Health, Medicine and Wellbeing, University of Newcastle, New Lambton Heights, New South Wales, Australia; School of Nursing and Midwifery, University of Newcastle, Callaghan, New South Wales, Australia.
  • Poon C; Cyclomedica Australia Pty Ltd, Kingsgrove, New South Wales, Australia.
  • Rutherford N; Department of Nuclear Medicine, John Hunter Hospital, New Lambton Heights, New South Wales, Australia.
  • Brooker B; Department of Nuclear Medicine, John Hunter Hospital, New Lambton Heights, New South Wales, Australia.
  • Smith A; Centre of Excellence in Treatable Traits, College of Health, Medicine and Wellbeing, University of Newcastle, New Lambton Heights, New South Wales, Australia; School of Nursing and Midwifery, University of Newcastle, Callaghan, New South Wales, Australia.
  • Grainge C; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, New South Wales, Australia.
  • Wark PAB; Department of Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia; Department of Respiratory Medicine, Alfred Health, Melbourne, VIC, Australia.
  • McDonald VM; Centre of Excellence in Treatable Traits, College of Health, Medicine and Wellbeing, University of Newcastle, New Lambton Heights, New South Wales, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, New South Wales, Australia; School of Nursing and Mi
J Allergy Clin Immunol Pract ; 12(4): 929-935.e4, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38151119
ABSTRACT

BACKGROUND:

Ventilation heterogeneity (VH) is a feature of asthma and indicates small airway disease. Nuclear imaging methods assess VH, which can facilitate clinical diagnosis and further our understanding of disease aetiology.

OBJECTIVE:

We sought to assess VH in severe eosinophilic asthma (SEA) using ventilation/perfusion single-photon emission computed tomography (V/P SPECT), and to assess its use as an objective test of the effect of biologic treatment for ventilation defects in SEA.

METHODS:

Adults (≥18 y) with severe asthma were recruited to participate in a cross-sectional observational study. Participants underwent a clinical assessment and V/P SPECT CT using Technegas as the ventilation agent. Measures were repeated for a nested before-after treatment study in people with SEA commencing biologics.

RESULTS:

A total of 62 participants with severe asthma were recruited. From this, 38 participants with SEA were included in the before-after study. The VH was associated with clinical variables such as lung function impairment and significantly improved after monoclonal antibody treatment in the severe asthma group. The changes in VH correlated with change in post bronchodilator forced expiratory volume in 1 second (FEV1) %predicted (r = -0.503; P = .001) and post bronchodilator FEV1/FVC (forced vital capacity) (r = -0.415; P = .01).

CONCLUSIONS:

The VH is clinically significant, measurable, and treatable, which establishes VH as a treatable trait in severe asthma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Enfermedad Pulmonar Obstructiva Crónica Límite: Adult / Humans Idioma: En Revista: J Allergy Clin Immunol Pract Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Enfermedad Pulmonar Obstructiva Crónica Límite: Adult / Humans Idioma: En Revista: J Allergy Clin Immunol Pract Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos