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Predicting cognitive decline: Which is more useful, baseline amyloid levels or longitudinal change?
Chen, Gengsheng; McKay, Nicole S; Gordon, Brian A; Liu, Jingxia; Joseph-Mathurin, Nelly; Schindler, Suzanne E; Hassenstab, Jason; Aschenbrenner, Andrew J; Wang, Qing; Schultz, Stephanie A; Su, Yi; LaMontagne, Pamela J; Keefe, Sarah J; Massoumzadeh, Parinaz; Cruchaga, Carlos; Xiong, Chengjie; Morris, John C; Benzinger, Tammie L S.
Afiliación
  • Chen G; Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  • McKay NS; Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  • Gordon BA; Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University in St. Louis Schoo
  • Liu J; Department of Surgery, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  • Joseph-Mathurin N; Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  • Schindler SE; Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  • Hassenstab J; Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  • Aschenbrenner AJ; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  • Wang Q; Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  • Schultz SA; Department of Neurology Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Su Y; Banner Alzheimer's Institute, Phoenix, AZ, USA.
  • LaMontagne PJ; Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  • Keefe SJ; Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  • Massoumzadeh P; Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  • Cruchaga C; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  • Xiong C; Divison of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  • Morris JC; Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University in St. Louis Schoo
  • Benzinger TLS; Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University in St. Louis Schoo
Neuroimage Clin ; 41: 103551, 2024.
Article en En | MEDLINE | ID: mdl-38150745
ABSTRACT
The use of biomarkers for the early detection of Alzheimer's disease (AD) is crucial for developing potential therapeutic treatments. Positron Emission Tomography (PET) is a well-established tool used to detect ß-amyloid (Aß) plaques in the brain. Previous studies have shown that cross-sectional biomarkers can predict cognitive decline (Schindler et al.,2021). However, it is still unclear whether longitudinal Aß-PET may have additional value for predicting time to cognitive impairment in AD. The current study aims to evaluate the ability of baseline- versus longitudinal rate of change in-11C-Pittsburgh compound B (PiB) Aß-PET to predict cognitive decline. A cohort of 153 participants who previously underwent PiB-PET scans and comprehensive clinical assessments were used in this study. Our analyses revealed that baseline Aß is significantly associated with the rate of change in cognitive composite scores, with cognition declining more rapidly when baseline PiB Aß levels were higher. In contrast, no signification association was identified between the rate of change in PiB-PET Aß and cognitive decline. Additionally, the ability of the rate of change in the PiB-PET measures to predict cognitive decline was significantly influenced by APOE ε4 carrier status. These results suggest that a single PiB-PET scan is sufficient to predict cognitive decline and that longitudinal measures of Aß accumulation do not improve the prediction of cognitive decline once someone is amyloid positive.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Límite: Humans Idioma: En Revista: Neuroimage Clin Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Límite: Humans Idioma: En Revista: Neuroimage Clin Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos