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Impact of RYGB surgery on plasma immunoglobulins: association between blood pressure and glucose levels six months after surgery.
Happonen, Natalie; Härma, Mari-Anne; Akhi, Ramin; Nissinen, Antti E; Savolainen, Markku J; Ruuth, Maija; Öörni, Katariina; Adeshara, Krishna; Lehto, Markku; Groop, Per-Henrik; Koivukangas, Vesa; Hukkanen, Janne; Hörkkö, Sohvi.
Afiliación
  • Happonen N; Medical Microbiology and Immunology, Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
  • Härma MA; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
  • Akhi R; Nordlab, Oulu University Hospital, Oulu, Finland.
  • Nissinen AE; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
  • Savolainen MJ; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Ruuth M; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Öörni K; Medical Microbiology and Immunology, Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
  • Adeshara K; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
  • Lehto M; Medical Microbiology and Immunology, Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
  • Groop PH; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
  • Koivukangas V; Research Unit of Biomedicine and Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland.
  • Hukkanen J; Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland.
  • Hörkkö S; Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland.
APMIS ; 132(3): 187-197, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38149431
ABSTRACT
We aimed to study levels of natural antibodies in plasma, and their associations to clinical and fecal biomarkers, before and 6 months after Roux-en-Y gastric bypass (RYGB) surgery. Thirty individuals with obesity [16 type 2 diabetic, 14 non-diabetic (ND)] had RYGB surgery. Total plasma IgA, IgG and IgM antibody levels and specific antibodies to oxidized low-density lipoprotein (oxLDL), malondialdehyde-acetaldehyde adducts, Porphyromonas gingivalis gingipain A hemagglutinin domain (Rgp44), and phosphocholine were measured using chemiluminescence immunoassay. Associations between plasma and fecal antibodies as well as clinical markers were analyzed. RYGB surgery reduced blood pressure, and the glycemic state was improved. A higher level of diastolic blood pressure was associated with lower plasma antibodies to oxLDL after surgery. Also, lower level of glucose markers associated with lower level of plasma antibodies to bacterial virulence factors. Antibodies to oxLDL decreased after surgery, and positive association between active serum lipopolysaccharide and specific oxLDL antibodies was detected. Total IgG levels decreased after surgery, but only in ND individuals. Reduced level of total plasma IgG, improved state of hypertension and hyperglycemia and their associations with decreased levels of specific antibodies in plasma, suggest an improved state of systemic inflammation after RYGB surgery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Derivación Gástrica / Diabetes Mellitus Tipo 2 Límite: Humans Idioma: En Revista: APMIS Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Derivación Gástrica / Diabetes Mellitus Tipo 2 Límite: Humans Idioma: En Revista: APMIS Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Dinamarca