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IVIG as a Promising Therapy for Methotrexate-induced Life-threatening Neutropenic Enterocolitis in an Elderly Patient With Rheumatoid Arthritis: A Case Report and Literature Review.
Lui, Shan-Wen; Lu, Jeng-Wei; Ho, Yi-Jung; Hsieh, Ting-Yu; Yeh, Fu-Chiang; Liu, Feng-Cheng.
Afiliación
  • Lui SW; School of Medicine, National Defense Medical Center, Taipei, Taiwan, R.O.C.
  • Lu JW; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
  • Ho YJ; The Finsen Laboratory, Rigshospitalet/National University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Hsieh TY; School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, R.O.C.
  • Yeh FC; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, R.O.C.
  • Liu FC; School of Medicine, National Defense Medical Center, Taipei, Taiwan, R.O.C.
In Vivo ; 38(1): 511-517, 2024.
Article en En | MEDLINE | ID: mdl-38148101
ABSTRACT
BACKGROUND/

AIM:

Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with the functional impairment of multiple joints and the destruction of bone and cartilage. Methotrexate (MTX) is a first-line drug commonly used to treat RA; however, even low doses of MTX can potentially cause rare but severe adverse reactions, such as neutropenic enterocolitis (NE), a life-threatening disease characterized by intestinal mucosal damage and immunodeficiency. CASE REPORT Here, we report on an 82-year-old RA patient who developed life-threatening NE after ten years of low-dose MTX treatment. The condition of the patient rapidly worsened, requiring emergency electrical cardioversion and intravenous treatment with immunoglobulin (IVIG). Immunophenotypic responses were analyzed before and after treatment to evaluate therapeutic efficacy.

CONCLUSION:

This case highlights the importance of monitoring elderly patients with RA receiving low-dose MTX treatment for the potential accumulation of MTX toxicity. Our findings also illustrate the importance of providing timely IVIG therapy for MTX-induced NE.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Enterocolitis Neutropénica Límite: Aged / Aged80 / Humans Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Enterocolitis Neutropénica Límite: Aged / Aged80 / Humans Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Grecia