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Expression patterns of CYP26A1, FGF8, CDKN1A, and NPVF in the developing rhesus monkey retina.
Krueger, Miranda R; Fishman-Williams, Elizabeth; Simó, Sergi; Tarantal, Alice F; La Torre, Anna.
Afiliación
  • Krueger MR; Department of Cell Biology and Human Anatomy, University of California, Davis, Davis, CA, 95616, United States.
  • Fishman-Williams E; Department of Cell Biology and Human Anatomy, University of California, Davis, Davis, CA, 95616, United States.
  • Simó S; Department of Cell Biology and Human Anatomy, University of California, Davis, Davis, CA, 95616, United States.
  • Tarantal AF; Department of Cell Biology and Human Anatomy, University of California, Davis, Davis, CA, 95616, United States; Department of Pediatrics, University of California, Davis, Davis, CA, 95616, United States; California National Primate Research Center, University of California, Davis, Davis, CA, 95616,
  • La Torre A; Department of Cell Biology and Human Anatomy, University of California, Davis, Davis, CA, 95616, United States. Electronic address: alatorre@ucdavis.edu.
Differentiation ; 135: 100743, 2024.
Article en En | MEDLINE | ID: mdl-38147763
ABSTRACT
The fovea centralis (fovea) is a specialized region of the primate retina that plays crucial roles in high-resolution visual acuity and color perception. The fovea is characterized by a high density of cone photoreceptors and no rods, and unique anatomical properties that contribute to its remarkable visual capabilities. Early histological analyses identified some of the key events that contribute to foveal development, but the mechanisms that direct the specification of this area are not understood. Recently, the expression of the retinoic acid-metabolizing enzyme CYP26A1 has become a hallmark of some of the retinal specializations found in vertebrates, including the primate fovea and the high-acuity area in avian species. In chickens, the retinoic acid pathway regulates the expression of FGF8 to then direct the development of a rod-free area. Similarly, high levels of CYP26A1, CDKN1A, and NPVF expression have been observed in the primate macula using transcriptomic approaches. However, which retinal cells express these genes and their expression dynamics in the developing primate eye remain unknown. Here, we systematically characterize the expression patterns of CYP26A1, FGF8, CDKN1A, and NPVF during the development of the rhesus monkey retina, from early stages of development in the first trimester until the third trimester (near term). Our data suggest that some of the markers previously proposed to be fovea-specific are not enriched in the progenitors of the rhesus monkey fovea. In contrast, CYP26A1 is expressed at high levels in the progenitors of the fovea, while it localizes in a subpopulation of macular Müller glia cells later in development. Together these data provide invaluable insights into the expression dynamics of several molecules in the nonhuman primate retina and highlight the developmental advancement of the foveal region.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retina / Pollos Límite: Animals Idioma: En Revista: Differentiation Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retina / Pollos Límite: Animals Idioma: En Revista: Differentiation Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido