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Peak Cone Density Predicted from Outer Segment Length Measured on Optical Coherence Tomography.
Heitkotter, Heather; Allphin, Mitchell T; Untaroiu, Ana; Min, Heun; Warr, Emma; Wynne, Niamh; Cooper, Robert F; Carroll, Joseph.
Afiliación
  • Heitkotter H; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Allphin MT; Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Untaroiu A; School of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Min H; School of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Warr E; Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Wynne N; Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.
  • Cooper RF; Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Carroll J; Joint Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, WI, USA.
Curr Eye Res ; 49(3): 314-324, 2024 03.
Article en En | MEDLINE | ID: mdl-38146597
ABSTRACT

PURPOSE:

To compare peak cone density predicted from outer segment length measured on optical coherence tomography with direct measures of peak cone density from adaptive optics scanning light ophthalmoscopy.

METHODS:

Data from 42 healthy participants with direct peak cone density measures and optical coherence tomography line scans available were used in this study. Longitudinal reflectivity profiles were analyzed using two methods of identifying the boundaries of the ellipsoid and interdigitation zones to estimate maximum outer segment length peak-to-peak and the slope method. These maximum outer segment length values were then used to predict peak cone density using a previously described geometrical model. A comparison between predicted and direct peak cone density measures was then performed.

RESULTS:

The mean bias between observers for estimating maximum outer segment length across methods was less than 2 µm. Cone density predicted from the peak-to-peak method against direct cone density measures showed a mean bias of 6,812 cones/mm2 with 50% of participants displaying a 10% difference or less between predicted and direct cone density values. Cone density derived from the slope method showed a mean bias of -17,929 cones/mm2 relative to direct cone density measures, with only 41% of participants demonstrating less than a 10% difference between direct and predicted cone density values.

CONCLUSION:

Predicted foveal cone density derived from peak-to-peak outer segment length measurements using commercial optical coherence tomography show modest agreement with direct measures of peak cone density from adaptive optics scanning light ophthalmoscopy. The methods used here are imperfect predictors of cone density, however, further exploration of this relationship could reveal a clinically relevant marker of cone structure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Fotorreceptoras Retinianas Conos / Tomografía de Coherencia Óptica Límite: Humans Idioma: En Revista: Curr Eye Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Fotorreceptoras Retinianas Conos / Tomografía de Coherencia Óptica Límite: Humans Idioma: En Revista: Curr Eye Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido