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Clinical Characteristics and Prognosis of Biliary Atresia with Low Serum Matrix Metalloproteinase-7 Levels.
Jiang, Jingying; Yang, Yifan; Ren, Xue; Xu, Chen; Ye, Chunjing; Zhou, Jin; Qian, Manning; Wang, Shuxin; Chen, Gong; Dong, Rui; Zheng, Shan.
Afiliación
  • Jiang J; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Shanghai, China.
  • Yang Y; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Shanghai, China.
  • Ren X; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Shanghai, China.
  • Xu C; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Shanghai, China.
  • Ye C; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Shanghai, China.
  • Zhou J; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Shanghai, China.
  • Qian M; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Shanghai, China.
  • Wang S; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Shanghai, China.
  • Chen G; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Shanghai, China.
  • Dong R; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Shanghai, China.
  • Zheng S; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Shanghai, China. Electronic address: szheng@shmu.edu.cn.
J Pediatr Surg ; 59(4): 648-652, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38145921
ABSTRACT

PURPOSE:

Serum matrix metalloproteinase-7 (MMP-7) levels can precisely differentiate biliary atresia (BA) from non-BA cholestasis. However, serum MMP-7 levels of some BA patients were within normal range or slightly elevated. This study aimed to investigate the clinical characteristics and prognosis of biliary atresia with low serum MMP-7 levels.

METHOD:

This is a retrospective cohort study. Cases of BA from July 2020 to December 2022 were consecutively enrolled. They were divided into low-MMP-7 group (MMP-7 ≤ 25 ng/ml) and high-MMP-7 group (MMP-7 > 25 ng/ml) according to serum MMP-7 levels preoperatively. The perioperative clinical characteristics, the 3-month and 6-month jaundice clearance rate post-Kasai procedure, and the native liver survival were compared between the two groups.

RESULTS:

A total of 329 cases were included in this study, 40 of which were divided into the low-MMP-7 group. Preoperative GGT and direct bilirubin levels in the low-MMP-7 group were significantly lower than those in the high-MMP-7 group (258.6 U/L, interquartile range [IQR] 160.4411.6 vs. 406.8 IU/L, IQR 215,655.0, P = 0.0076; 103.8 µmol/L, IQR 79.0,121.4 vs. 115.3 µmol/L, IQR 94,138.8, P = 0.0071), while the gender, the day at surgery and preoperative ALT, AST, TBA, total bilirubin levels showed no significant differences (P > 0.05). The 3-month and 6-month jaundice clearance rate post-Kasai procedure in the low-MMP-7 group were lower than those in the high-MMP-7 group (29.73% vs. 53.09%, P = 0.049; 32.14% vs. 54.73%, P = 0.023). The 1-year native liver survival rate was 29.63% for the low-MMP-7 group and 53.02% for the high-MMP-7 group (P = 0.022).

CONCLUSION:

Preoperative clinical characteristics were similar between low-MMP-7 group and high-MMP-7 group, while patients with low serum MMP-7 levels showed worse prognosis, indicating that this might be listed as a new clinical subtype of BA which could contribute to designing new treatment strategies for BA in the future. STUDY TYPE Cohort Study. LEVEL OF EVIDENCE Level II.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atresia Biliar / Ictericia Límite: Humans / Infant Idioma: En Revista: J Pediatr Surg Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atresia Biliar / Ictericia Límite: Humans / Infant Idioma: En Revista: J Pediatr Surg Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos