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Controlled electroactive release from solid-state conductive elastomer electrodes.
Chapman, Christopher A R; Fernandez-Patel, Shanila; Jahan, Nusrat; Cuttaz, Estelle A; Novikov, Alexey; Goding, Josef A; Green, Rylie A.
Afiliación
  • Chapman CAR; School of Engineering and Materials Science, Queen Mary University of London, Mile End, London, E1 4NS, UK.
  • Fernandez-Patel S; Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.
  • Jahan N; Tumour Immunogenomics and Immunosurveillance Laboratory, University College London Cancer Institute, London, UK.
  • Cuttaz EA; Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.
  • Novikov A; Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.
  • Goding JA; Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.
  • Green RA; Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.
Mater Today Bio ; 23: 100883, 2023 Dec.
Article en En | MEDLINE | ID: mdl-38144517
ABSTRACT
This work highlights the development of a conductive elastomer (CE) based electrophoretic platform that enables the transfer of charged molecules from a solid-state CE electrode directly to targeted tissues. Using an elastomer-based electrode containing poly (3,4-ethylenedioxythiophene) nanowires, controlled electrophoretic delivery of methylene blue (MB) and fluorescein (FLSC) was achieved with applied voltage. Electroactive release of positively charged MB and negatively charged FLSC achieved 33.19 ± 6.47 µg release of MB and 22.36 ± 3.05 µg release of FLSC, a 24 and 20-fold increase in comparison to inhibitory voltages over 1 h. Additionally, selective, and sequential release of the two oppositely charged molecules from a single CE device was demonstrated, showing the potential of this device to be used in multi-drug treatments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mater Today Bio Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mater Today Bio Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido