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Validation of disease severity index for predicting complicated disease in Crohn's disease: A comparison study with Lémann index.
Qiu, Yun; Zhou, Longyuan; Lu, Baolan; Lin, Xiaoqing; Chen, Baili; He, Yao; Zeng, Zhirong; Chen, Minhu; Li, Xuehua; Mao, Ren.
Afiliación
  • Qiu Y; Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China. Electronic address: qyun@mail2.sysu.edu.cn.
  • Zhou L; Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
  • Lu B; Department of Radiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
  • Lin X; Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
  • Chen B; Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
  • He Y; Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
  • Zeng Z; Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
  • Chen M; Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
  • Li X; Department of Radiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
  • Mao R; Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China. Electronic address: maor5@mail.sysu.edu.cn.
Dig Liver Dis ; 56(4): 635-640, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38143189
ABSTRACT

BACKGROUND:

Disease Severity Index (DSI) provides comprehensive assessment of bowel damage (BD).

AIMS:

To evaluate DSI in patients with Crohn's disease (CD) at high risk of disease progression, compared to Lémann Index (LI).

METHODS:

Patients with CD in our center were reviewed consecutively between 2017 and 2019. DSI, LI, and complicated CD course were analyzed.

RESULTS:

The median LI and DSI of included 300 patients were 1.63 (IQR 1.25-3.13) and 42 (IQR 32-51), respectively. 152 patients (50.7%) experienced a complicated disease course (median 5.1 months; IQR 1.1-20.2). DSI (AUC 0.66; 95% CI 0.60-0.72) better predicted a complicated course of CD over LI (AUC 0.56; 95% CI 0.50-0.63; P = 0.007). The cumulative probability of complicated CD course in severe patients was higher than those with 'mild CD' (P < 0.001). The Cox analysis identified DSI>43 (HR 2.18; 95% CI 1.54-3.09; P < 0.001), B2/3 vs. B1 (HR 2.80; 95% CI 1.99-3.94; P < 0.001), and a higher level of CRP (HR 1.01; 95% CI 1.00-1.02; P = 0.005) as independent prognostic factors for complicated CD. However, LI was not associated with complicated CD (P = 0.164).

CONCLUSIONS:

Higher DSI was associated with complicated disease outcomes. DSI might play a better role than LI in identifying patients at high risks of disease progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Crohn Límite: Humans Idioma: En Revista: Dig Liver Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Crohn Límite: Humans Idioma: En Revista: Dig Liver Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos