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Nanoscale surface coatings and topographies for neural interfaces.
Cho, Younghak; Choi, Yunyoung; Seong, Hyejeong.
Afiliación
  • Cho Y; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
  • Choi Y; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
  • Seong H; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea; Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Seoul, Republic of Korea. Electronic address: h.seong@kist.re.kr.
Acta Biomater ; 175: 55-75, 2024 02.
Article en En | MEDLINE | ID: mdl-38141934
ABSTRACT
With the lack of minimally invasive tools for probing neuronal systems across spatiotemporal scales, understanding the working mechanism of the nervous system and limited assessments available are imperative to prevent or treat neurological disorders. In particular, nanoengineered neural interfaces can provide a solution to this technological barrier. This review covers recent surface engineering approaches, including nanoscale surface coatings, and a range of topographies from the microscale to the nanoscale, primarily focusing on neural-interfaced biosystems. Specifically, the immobilization of bioactive molecules to fertilize the neural cell lineage, topographical engineering to induce mechanotransduction in neural cells, and enhanced cell-chip coupling using three-dimensional structured surfaces are highlighted. Advances in neural interface design will help us understand the nervous system, thereby achieving the effective treatments for neurological disorders. STATEMENT OF

SIGNIFICANCE:

• This review focuses on designing bioactive neural interface with a nanoscale chemical modification and topographical engineering at multiscale perspective. • Versatile nanoscale surface coatings and topographies for neural interface are summarized. • Recent advances in bioactive materials applicable for neural cell culture, electrophysiological sensing, and neural implants are reviewed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mecanotransducción Celular / Enfermedades del Sistema Nervioso Límite: Humans Idioma: En Revista: Acta Biomater Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mecanotransducción Celular / Enfermedades del Sistema Nervioso Límite: Humans Idioma: En Revista: Acta Biomater Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido