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Development of cassava starch-based films incorporated with phenolic compounds produced by an Amazonian fungus.
Falcão, Lucas de Souza; Oliveira, Isabella de Lima; Gurgel, Raiana Silveira; de Souza, Anne Terezinha Fernandes; Mendonça, Leilane de Souza; Usuda, Érik Oda; do Amaral, Thaís Santiago; Veggi, Priscilla Carvalho; Campelo, Pedro Henrique; de Vasconcellos, Marne Carvalho; Albuquerque, Patrícia Melchionna; de Moraes, Mariana Agostini.
Afiliación
  • Falcão LS; School of Technology, Amazonas State University, UEA, Manaus, AM, Brazil; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, UNIFESP, Diadema, SP, Brazil.
  • Oliveira IL; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, UNIFESP, Diadema, SP, Brazil.
  • Gurgel RS; School of Technology, Amazonas State University, UEA, Manaus, AM, Brazil.
  • de Souza ATF; School of Technology, Amazonas State University, UEA, Manaus, AM, Brazil.
  • Mendonça LS; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, UFAM, Manaus, AM, Brazil.
  • Usuda ÉO; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, UNIFESP, Diadema, SP, Brazil.
  • do Amaral TS; School of Technology, Amazonas State University, UEA, Manaus, AM, Brazil.
  • Veggi PC; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, UNIFESP, Diadema, SP, Brazil.
  • Campelo PH; Department of Food Technology, Federal University of Viçosa, Viçosa, MG, Brazil.
  • de Vasconcellos MC; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, UFAM, Manaus, AM, Brazil.
  • Albuquerque PM; School of Technology, Amazonas State University, UEA, Manaus, AM, Brazil.
  • de Moraes MA; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, UNIFESP, Diadema, SP, Brazil; School of Chemical Engineering, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil. Electronic address: agostini@unicamp.br.
Int J Biol Macromol ; 258(Pt 1): 128882, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38141712
ABSTRACT
Drug-release systems have attracted attention over the last few years since they can be used as a substitute for traditional methods of drug delivery. These have the advantage of being directly administered at the treatment site and can maintain the drug at adequate levels for a longer period, thus increasing their efficacy. Starch-based films are interesting candidates for use as matrices for drug release, especially due to starch's non-toxic properties and its biocompatibility. Endophytic fungi are an important source of bioactive molecules, including secondary metabolites such as phenolic compounds with antioxidant activity. In the present study, cassava starch-based films were developed to act as release systems of phenolic compounds with antioxidant activity. The Amazonian endophytic fungus Aspergillus niger MgF2 was cultivated in liquid media, and the fungal extract was obtained by liquid-liquid partition with ethyl acetate. The starch-based films incorporated with the fungal extract were characterized in regards to their physicochemical properties. The release kinetics of the extract from the film and its antioxidant and cytotoxic properties were also evaluated. The films incorporated with the extract presented maximum release after 25 min at 37 °C and pH 6.8. In addition, it was observed that the antioxidant compounds of the fungal extract maintain their activity after being released from the film, and were non-toxic. Therefore, considering the promising physicochemical properties of the extract-incorporated films, and their considerable antioxidant capacity, the films demonstrate great biotechnological potential with diverse applications in the pharmacological and cosmetic industries.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Manihot / Antioxidantes Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Manihot / Antioxidantes Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos