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What Are the Key Anatomical Features for the Success of Nose-to-Brain Delivery? A Study of Powder Deposition in 3D-Printed Nasal Casts.
Rigaut, Clément; Deruyver, Laura; Niesen, Maxime; Vander Ghinst, Marc; Goole, Jonathan; Lambert, Pierre; Haut, Benoit.
Afiliación
  • Rigaut C; Transfers Interfaces and Processes (TIPs), École Polytechnique de Bruxelles, Université Libre de Bruxelles, 1050 Brussels, Belgium.
  • Deruyver L; Laboratoire de Pharmacie Galénique et Biopharmacie, Faculté de Pharmacie, Université Libre de Bruxelles, 1050 Brussels, Belgium.
  • Niesen M; Department of Ear, Nose and Throat and Cervico-Facial Surgery, CUB Hôpital Erasme, Hôpital de Bruxelles (HUB), 1070 Brussels, Belgium.
  • Vander Ghinst M; Department of Ear, Nose and Throat and Cervico-Facial Surgery, CUB Hôpital Erasme, Hôpital de Bruxelles (HUB), 1070 Brussels, Belgium.
  • Goole J; Laboratoire de Pharmacie Galénique et Biopharmacie, Faculté de Pharmacie, Université Libre de Bruxelles, 1050 Brussels, Belgium.
  • Lambert P; Transfers Interfaces and Processes (TIPs), École Polytechnique de Bruxelles, Université Libre de Bruxelles, 1050 Brussels, Belgium.
  • Haut B; Transfers Interfaces and Processes (TIPs), École Polytechnique de Bruxelles, Université Libre de Bruxelles, 1050 Brussels, Belgium.
Pharmaceutics ; 15(12)2023 Nov 23.
Article en En | MEDLINE | ID: mdl-38140002
ABSTRACT
Nose-to-brain delivery is a promising way to improve the treatment of central nervous system disorders, as it allows the bypassing of the blood-brain barrier. However, it is still largely unknown how the anatomy of the nose can influence the treatment outcome. In this work, we used 3D printing to produce nasal replicas based on 11 different CT scans presenting various anatomical features. Then, for each anatomy and using the Design of Experiments methodology, we characterised the amount of a powder deposited in the olfactory region of the replica as a function of multiple parameters (choice of the nostril, device, orientation angle, and the presence or not of a concomitant inspiration flow). We found that, for each anatomy, the maximum amount of powder that can be deposited in the olfactory region is directly proportional to the total area of this region. More precisely, the results show that, whatever the instillation strategy, if the total area of the olfactory region is below 1500 mm2, no more than 25% of an instilled powder can reach this region. On the other hand, if the total area of the olfactory region is above 3000 mm2, the deposition efficiency reaches 50% with the optimal choice of parameters, whatever the other anatomical characteristics of the nasal cavity. Finally, if the relative difference between the areas of the two sides of the internal nasal valve is larger than 20%, it becomes important to carefully choose the side of instillation. This work, by predicting the amount of powder reaching the olfactory region, provides a tool to evaluate the adequacy of nose-to-brain treatment for a given patient. While the conclusions should be confirmed via in vivo studies, it is a first step towards personalised treatment of neurological pathologies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2023 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2023 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Suiza