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The Negative Impact of Inflammation-Related Parameters in Prostate Cancer after Robot-Assisted Radical Prostatectomy: A Retrospective Multicenter Cohort Study in Japan (the MSUG94 Group).
Murase, Kazumasa; Kawase, Makoto; Ebara, Shin; Tatenuma, Tomoyuki; Sasaki, Takeshi; Ikehata, Yoshinori; Nakayama, Akinori; Toide, Masahiro; Yoneda, Tatsuaki; Sakaguchi, Kazushige; Teishima, Jun; Makiyama, Kazuhide; Inoue, Takahiro; Kitamura, Hiroshi; Saito, Kazutaka; Koga, Fumitaka; Urakami, Shinji; Koie, Takuya.
Afiliación
  • Murase K; Department of Urology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
  • Kawase M; Department of Urology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
  • Ebara S; Department of Urology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima 730-8518, Japan.
  • Tatenuma T; Department of Urology, Yokohama City University, Yokohama 236-0004, Japan.
  • Sasaki T; Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.
  • Ikehata Y; Department of Urology, University of Toyama, Toyama 930-0194, Japan.
  • Nakayama A; Department of Urology, Dokkyo Medical University Saitama Medical Center, Koshigaya 343-8555, Japan.
  • Toide M; Department of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-8677, Japan.
  • Yoneda T; Department of Urology, Seirei Hamamatsu General Hospital, Hamamatsu 430-8558, Japan.
  • Sakaguchi K; Department of Urology, Toranomon Hospital, Tokyo 105-8470, Japan.
  • Teishima J; Department of Surgery, Division of Urology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
  • Makiyama K; Department of Urology, Yokohama City University, Yokohama 236-0004, Japan.
  • Inoue T; Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.
  • Kitamura H; Department of Urology, University of Toyama, Toyama 930-0194, Japan.
  • Saito K; Department of Urology, Dokkyo Medical University Saitama Medical Center, Koshigaya 343-8555, Japan.
  • Koga F; Department of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-8677, Japan.
  • Urakami S; Department of Urology, Toranomon Hospital, Tokyo 105-8470, Japan.
  • Koie T; Department of Urology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
J Clin Med ; 12(24)2023 Dec 17.
Article en En | MEDLINE | ID: mdl-38137801
ABSTRACT
Background and

Objectives:

We aimed to examine the relationship between the inflammation-related parameters, such as the neutrophil-to-lymphocyte ratio (NLR), and the pathological findings and biochemical recurrence (BCR) in patients with prostate cancer (PCa) undergoing robot-assisted radical prostatectomy (RARP). Materials and

Methods:

A retrospective multicenter cohort study of patients with PCa who underwent RARP at 10 institutes in Japan was conducted. This study enrolled 3195 patients. We focused on patients undergoing RARP who underwent the preoperative measurement of their inflammation-related parameters and who did not receive any neo- or adjuvant therapy. Data on the pre- and postoperative variables for the enrolled patients were obtained. The primary endpoint of this study was the association between BCR and the inflammation-related parameters after RARP. The secondary endpoint was the association between the inflammation-related parameters and the pathological diagnosis of PCa.

Results:

Data from 2429 patients with PCa who met the study's eligibility criteria were analyzed. The median follow-up period was 25.1 months. The inflammation-related parameters were divided into two groups, and cutoff values were determined based on the receiver operating characteristics. There were no statistically significant differences in biochemical recurrence-free survival for any of the parameters. In the univariate analysis, the NLR was predictive of pathological T3 and lymphovascular invasion; however, there were no significant differences in the multivariate analysis.

Conclusions:

The inflammation-related parameters did not significantly affect the incidence of BCR, at least among patients with PCa who underwent RARP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza