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Differential Study of Retinal Thicknesses in the Eyes of Alzheimer's Patients, Multiple Sclerosis Patients and Healthy Subjects.
Garcia-Martin, Elena; Jimeno-Huete, Daniel; Dongil-Moreno, Francisco J; Boquete, Luciano; Sánchez-Morla, Eva M; Miguel-Jiménez, Juan M; López-Dorado, Almudena; Vilades, Elisa; Fuertes, Maria I; Pueyo, Ana; Ortiz Del Castillo, Miguel.
Afiliación
  • Garcia-Martin E; Department of Ophthalmology, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
  • Jimeno-Huete D; Miguel Servet Ophthalmology Innovation and Research Group (GIMSO), Aragon Institute for Health Research (IIS Aragon), Biotech Vision SLP (Spin-Off Company), University of Zaragoza, 50009 Zaragoza, Spain.
  • Dongil-Moreno FJ; Biomedical Engineering Group, Department of Electronics, University of Alcalá, 28871 Alcalá de Henares, Spain.
  • Boquete L; Biomedical Engineering Group, Department of Electronics, University of Alcalá, 28871 Alcalá de Henares, Spain.
  • Sánchez-Morla EM; Biomedical Engineering Group, Department of Electronics, University of Alcalá, 28871 Alcalá de Henares, Spain.
  • Miguel-Jiménez JM; Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
  • López-Dorado A; School of Medicine, Universidad Complutense, 28040 Madrid, Spain.
  • Vilades E; Biomedical Engineering Group, Department of Electronics, University of Alcalá, 28871 Alcalá de Henares, Spain.
  • Fuertes MI; Biomedical Engineering Group, Department of Electronics, University of Alcalá, 28871 Alcalá de Henares, Spain.
  • Pueyo A; Department of Ophthalmology, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
  • Ortiz Del Castillo M; Miguel Servet Ophthalmology Innovation and Research Group (GIMSO), Aragon Institute for Health Research (IIS Aragon), Biotech Vision SLP (Spin-Off Company), University of Zaragoza, 50009 Zaragoza, Spain.
Biomedicines ; 11(12)2023 Nov 24.
Article en En | MEDLINE | ID: mdl-38137347
ABSTRACT
Multiple sclerosis (MS) and Alzheimer's disease (AD) cause retinal thinning that is detectable in vivo using optical coherence tomography (OCT). To date, no papers have compared the two diseases in terms of the structural differences they produce in the retina. The purpose of this study is to analyse and compare the neuroretinal structure in MS patients, AD patients and healthy subjects using OCT. Spectral domain OCT was performed on 21 AD patients, 33 MS patients and 19 control subjects using the Posterior Pole protocol. The area under the receiver operating characteristic (AUROC) curve was used to analyse the differences between the cohorts in nine regions of the retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL) and outer nuclear layer (ONL). The main differences between MS and AD are found in the ONL, in practically all the regions analysed (AUROCFOVEAL = 0.80, AUROCPARAFOVEAL = 0.85, AUROCPERIFOVEAL = 0.80, AUROC_PMB = 0.77, AUROCPARAMACULAR = 0.85, AUROCINFERO_NASAL = 0.75, AUROCINFERO_TEMPORAL = 0.83), and in the paramacular zone (AUROCPARAMACULAR = 0.75) and infero-temporal quadrant (AUROCINFERO_TEMPORAL = 0.80) of the GCL. In conclusion, our findings suggest that OCT data analysis could facilitate the differential diagnosis of MS and AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza