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Low-Grade Gliomas: Histological Subtypes, Molecular Mechanisms, and Treatment Strategies.
Toader, Corneliu; Eva, Lucian; Costea, Daniel; Corlatescu, Antonio Daniel; Covache-Busuioc, Razvan-Adrian; Bratu, Bogdan-Gabriel; Glavan, Luca Andrei; Costin, Horia Petre; Popa, Andrei Adrian; Ciurea, Alexandru Vlad.
Afiliación
  • Toader C; Department of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Eva L; Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, 077160 Bucharest, Romania.
  • Costea D; Department of Neurosurgery, Dunarea de Jos University, 800010 Galati, Romania.
  • Corlatescu AD; Department of Neurosurgery, Clinical Emergency Hospital "Prof. Dr. Nicolae Oblu", 700309 Iasi, Romania.
  • Covache-Busuioc RA; Department of Neurosurgery, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
  • Bratu BG; Department of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Glavan LA; Department of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Costin HP; Department of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Popa AA; Department of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Ciurea AV; Department of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Brain Sci ; 13(12)2023 Dec 09.
Article en En | MEDLINE | ID: mdl-38137148
ABSTRACT
Low-Grade Gliomas (LGGs) represent a diverse group of brain tumors originating from glial cells, characterized by their unique histopathological and molecular features. This article offers a comprehensive exploration of LGGs, shedding light on their subtypes, histological and molecular aspects. By delving into the World Health Organization's grading system, 5th edition, various specificities were added due to an in-depth understanding of emerging laboratory techniques, especially genomic analysis. Moreover, treatment modalities are extensively discussed. The degree of surgical resection should always be considered according to postoperative quality of life and cognitive status. Adjuvant therapies focused on chemotherapy and radiotherapy depend on tumor grading and invasiveness. In the current literature, emerging targeted molecular therapies are well discussed due to their succinctly therapeutic effect; in our article, those therapies are summarized based on posttreatment results and possible adverse effects. This review serves as a valuable resource for clinicians, researchers, and medical professionals aiming to deepen their knowledge on LGGs and enhance patient care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Sci Año: 2023 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Sci Año: 2023 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza