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Neighborhood-level vaccine impact on COVID-19 infection and hospital admission in Quebec, Canada, during the Delta and early Omicron periods.
Lo, Ernest; Brousseau, Nicholas; Defay, Fannie; Fortin, Élise; Kiely, Marilou.
Afiliación
  • Lo E; Institut national de santé publique du Québec (INSPQ), Québec, QC, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada. Electronic address: ernest.lo@inspq.qc.ca.
  • Brousseau N; Institut national de santé publique du Québec (INSPQ), Québec, QC, Canada; Département de médecine sociale et préventive, Université Laval, Québec, QC, Canada; Centre de Recherche du CHU de Québec - Université Laval, Québec, QC, Canada. Electronic address: nicholas.brousseau@inspq.qc.ca.
  • Defay F; Institut national de santé publique du Québec (INSPQ), Québec, QC, Canada. Electronic address: fannie.defay@inspq.qc.ca.
  • Fortin É; Institut national de santé publique du Québec (INSPQ), Québec, QC, Canada; Département de médecine sociale et préventive, Université Laval, Québec, QC, Canada; Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, QC, Canada. Electronic address: elise.fortin@i
  • Kiely M; Institut national de santé publique du Québec (INSPQ), Québec, QC, Canada; Centre de Recherche du CHU de Québec - Université Laval, Québec, QC, Canada. Electronic address: marilou.kiely@inspq.qc.ca.
Vaccine ; 42(3): 636-644, 2024 Jan 25.
Article en En | MEDLINE | ID: mdl-38135643
ABSTRACT

OBJECTIVE:

To assess the impact of COVID-19 vaccination on COVID-19 infection and hospitalisation at the population-level, and to assess the indirect effects of vaccination in the province of Quebec, Canada.

METHODS:

We performed a time-stratified, neighborhood-level ecologic study. The exposure was neighborhood-level vaccination (primary series) coverage; outcomes were COVID-19 infection and hospitalisation rates. We used robust Poisson regression to estimate weekly relative rates of infection and hospitalisation versus vaccination.

RESULTS:

Higher vaccination coverage was associated with lower COVID-19 infection rates from July 18-December 4 for the year 2021 (Delta period) (RR≈0.46 [0.39; 0.54] - 0.94 [0.83; 1.05], 85-100% vs. 60-74% coverage). From December 5-December 25, this association reversed (RR≈1.28 [1.16; 1.41] - 1.41 [1.31; 1.52]), possibly due to the Omicron variant, social behaviors and accumulation of susceptibles in more vaccinated neighborhoods. Vaccine impact against hospitalisation was maintained throughout (RR≈0.43 [0.29; 0.65] - 0.88 [0.64; 1.22]). Vaccination provided substantial indirect protection (RR≈0.43 [0.34; 0.54] - 0.81 [0.65; 1.03]).

CONCLUSIONS:

This study confirmed the protective impact of vaccination against severe disease regardless of variant, at the population level. Ecological analyses are a valuable strategy to evaluate vaccination programs. Population-level effects can have substantial effects and should be accounted for in public health and vaccination program planning.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / COVID-19 Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Vaccine Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / COVID-19 Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Vaccine Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos