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Amide proton transfer-weighted MRI for renal tumors: Comparison with diffusion-weighted imaging.
Xu, Yun; Wan, Qingxuan; Ren, Xihui; Jiang, Yutao; Wang, Fang; Yao, Jing; Wu, Peng; Shen, Aijun; Wang, Peijun.
Afiliación
  • Xu Y; Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China; Institute of Medical Imaging Artificial Intelligence, Tongji University School of Medicine, Shanghai 200065, China.
  • Wan Q; Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China; Institute of Medical Imaging Artificial Intelligence, Tongji University School of Medicine, Shanghai 200065, China.
  • Ren X; Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China; Institute of Medical Imaging Artificial Intelligence, Tongji University School of Medicine, Shanghai 200065, China.
  • Jiang Y; Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China; Institute of Medical Imaging Artificial Intelligence, Tongji University School of Medicine, Shanghai 200065, China.
  • Wang F; Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China; Institute of Medical Imaging Artificial Intelligence, Tongji University School of Medicine, Shanghai 200065, China.
  • Yao J; Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China; Institute of Medical Imaging Artificial Intelligence, Tongji University School of Medicine, Shanghai 200065, China.
  • Wu P; Philips Healthcare, Shanghai 200072, China.
  • Shen A; Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China; Institute of Medical Imaging Artificial Intelligence, Tongji University School of Medicine, Shanghai 200065, China. Electronic address: sajdzyx@126.com.
  • Wang P; Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China; Institute of Medical Imaging Artificial Intelligence, Tongji University School of Medicine, Shanghai 200065, China. Electronic address: tongjipeijunwang@sina.com.
Magn Reson Imaging ; 106: 104-109, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38135260
ABSTRACT

OBJECTIVE:

To investigate the potential of amide proton transfer-weighted (APTw) MRI in identifying benign and malignant renal tumors and to evaluate whether APTw MRI can add diagnostic value to diffusion-weighted imaging (DWI). MATERIALS AND

METHODS:

Participants with renal tumor underwent preoperative multiparametric MRI, including APTw MRI and DWI. The APTw and apparent diffusion coefficient (ADC) of malignant tumors and benign tumors were calculated independently by two radiologists and compared. The value of the mean APTw and the mean ADC for differentiating malignant and benign tumors was evaluated by receiver operating characteristic analysis.

RESULTS:

In total, 65 participants (mean age, 59 years ±14; 41 men) were evaluated 54 with malignant and 11 with benign renal tumors. Malignant renal tumors showed higher mean APTw values [2.03% (1.63) vs 1.00% (1.60); P < 0.01] and lower mean ADC values (1.22 × 10-3 mm2/s ± 0.37 vs 1.51 × 10-3 mm2/s ± 0.37; P < 0.05) than benign renal tumors. The area under the receiver operating characteristic curve (AUC) of APTw, ADC and the combination of them for the identification of benign and malignant renal tumors was 0.78(95% CI 0.66, 0.87; P < 0.001),0.70(95% CI 0.54, 0.86; P < 0.05) and 0.79 (95% CI 0.67, 0.88; P < 0.001). The optimal cutoff value for mean APTw was 2.14% (sensitivity, 74%; specificity, 73%). There was no difference between these three parameters for differentiating malignant from benign renal tumors (P > 0.05).

CONCLUSION:

The APTw MRI has the potential use as an imaging biomarker for renal malignant and benign tumors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protones / Neoplasias Renales Límite: Humans / Male / Middle aged Idioma: En Revista: Magn Reson Imaging Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protones / Neoplasias Renales Límite: Humans / Male / Middle aged Idioma: En Revista: Magn Reson Imaging Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos