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Exposure to phenols reduces melanogenesis in B16F10 cells and zebrafish.
Lin, Chung-Yu; Wu, Chang-Yi; Wang, Chia C; Lee, Che-Hsin.
Afiliación
  • Lin CY; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
  • Wu CY; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
  • Wang CC; Department of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan; Aerosol Science Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
  • Lee CH; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan; Aerosol Science Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40433, Taiwan;
Aquat Toxicol ; 266: 106806, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38134820
ABSTRACT
Phenols, ubiquitous environmental contaminants found in water, soil, and air, pose risks to organisms even at minimal concentrations, and many are classified as hazardous pollutants. Skin pigmentation is a natural shield against ultraviolet-induced DNA damage and oxidative stress, pivotal in reducing skin cancer incidences. Studies on B16F10 melanoma cells and zebrafish offer valuable insights into potential therapeutic avenues for melanoma in the context of phenol exposure. Upon phenol treatment, there was a marked decrease in melanin content and melanogenesis-associated protein expression, such as tyrosinase and the microphthalmia-associated transcription factor (MITF) in these melanoma cells. Additionally, phenols led to diminished p38 phosphorylation, amplified extracellular signal-regulated kinase (ERK) phosphorylation, and curtailed melanin expression in zebrafish. These observations underscore the detrimental impact of phenols on melanogenesis and propose a mechanism of action centered on the ERK/p38 signaling pathway. Consequently, our data spotlight the adverse effects of phenols on melanogenesis."
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Melanoma Límite: Animals Idioma: En Revista: Aquat Toxicol Asunto de la revista: BIOLOGIA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Melanoma Límite: Animals Idioma: En Revista: Aquat Toxicol Asunto de la revista: BIOLOGIA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos