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Tumor-Derived Exosomal LINC01480 Upregulates VCAM1 Expression by Acting as a Competitive Endogenous RNA of miR-204-5p to Promote Gastric Cancer Progression.
Zhang, Yu; Guo, Shan; Mao, Tao; Guo, Jing; Zhang, Qi; Tian, Zibin; Li, Xiaoyu.
Afiliación
  • Zhang Y; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China.
  • Guo S; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China.
  • Mao T; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China.
  • Guo J; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China.
  • Zhang Q; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China.
  • Tian Z; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China.
  • Li X; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China.
ACS Biomater Sci Eng ; 10(1): 550-562, 2024 01 08.
Article en En | MEDLINE | ID: mdl-38133901
ABSTRACT
Exosomes are a type of cell-derived vesicles that range in size from 30 to 100 nm. They are widely present in various organisms and participate in diverse biological processes, playing crucial roles in tumorigenesis and progression. This study aimed to investigate whether LINC01480 in tumor-derived exosomes is involved in the molecular mechanism of gastric cancer by competitively upregulating the VCAM1 expression through binding miR-204-5p. The study analyzed transcriptome data related to gastric cancer from the cancer genome atlas database and constructed a risk-scoring model for epithelial-mesenchymal transition (EMT)-related lncRNAs to identify eight EMT-related lncRNAs associated with prognosis. EMT-related mRNAs positively correlated with LINC01480 were screened in the ExoRBase database. In vitro cell experiments showed that exosomal LINC01480 can promote the proliferation, migration, invasion, and EMT of gastric cancer cells by upregulating VCAM1 expression through competitive binding with miR-204-5p. In vivo experiments on nude mice showed that exosomal LINC01480 promotes the development of gastric cancer. These results suggest that exosomal LINC01480 could be a potential therapeutic target for gastric cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / MicroARNs / ARN Largo no Codificante Límite: Animals Idioma: En Revista: ACS Biomater Sci Eng Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / MicroARNs / ARN Largo no Codificante Límite: Animals Idioma: En Revista: ACS Biomater Sci Eng Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos