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Single-Cell Sequencing Technology and Its Application in the Study of Central Nervous System Diseases.
Ding, Yang; Peng, Yu-Yuan; Li, Sen; Tang, Can; Gao, Jie; Wang, Hai-Yan; Long, Zai-Yun; Lu, Xiu-Min; Wang, Yong-Tang.
Afiliación
  • Ding Y; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
  • Peng YY; State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
  • Li S; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
  • Tang C; State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
  • Gao J; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
  • Wang HY; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
  • Long ZY; State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
  • Lu XM; State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
  • Wang YT; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China. luxm@cqut.edu.cn.
Cell Biochem Biophys ; 82(2): 329-342, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38133792
ABSTRACT
The mammalian central nervous system consists of a large number of cells, which contain not only different types of neurons, but also a large number of glial cells, such as astrocytes, oligodendrocytes, and microglia. These cells are capable of performing highly refined electrophysiological activities and providing the brain with functions such as nutritional support, information transmission and pathogen defense. The diversity of cell types and individual differences between cells have brought inspiration to the study of the mechanism of central nervous system diseases. In order to explore the role of different cells, a new technology, single-cell sequencing technology has emerged to perform specific analysis of high-throughput cell populations, and has been continuously developed. Single-cell sequencing technology can accurately analyze single-cell expression in mixed-cell populations and collect cells from different spatial locations, time stages and types. By using single-cell sequencing technology to compare gene expression profiles of normal and diseased cells, it is possible to discover cell subsets associated with specific diseases and their associated genes. Therefore, scientists can understand the development process, related functions and disease state of the nervous system from an unprecedented depth. In conclusion, single-cell sequencing technology provides a powerful technology for the discovery of novel therapeutic targets for central nervous system diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Central / Análisis de la Célula Individual Límite: Animals / Humans Idioma: En Revista: Cell Biochem Biophys Asunto de la revista: BIOFISICA / BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Central / Análisis de la Célula Individual Límite: Animals / Humans Idioma: En Revista: Cell Biochem Biophys Asunto de la revista: BIOFISICA / BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos