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Relationships between Charlson comorbidity index associated biomarkers and outcomes among participants in the Malmö diet and cancer study.
Wessman, Torgny; Ruge, Toralph; Carlsson, Axel Carl; Wändell, Per; Khoshnood, Ardavan; Melander, Olle.
Afiliación
  • Wessman T; Department of Emergency and Internal Medicine, Skåne University Hospital, Malmö, Sweden.
  • Ruge T; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
  • Carlsson AC; Department of Emergency and Internal Medicine, Skåne University Hospital, Malmö, Sweden.
  • Wändell P; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
  • Khoshnood A; Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Huddinge, Sweden.
  • Melander O; Academic Primary Care Center, Stockholm, Sweden.
Biomarkers ; 28(8): 722-730, 2023 Dec.
Article en En | MEDLINE | ID: mdl-38133614
ABSTRACT

INTRODUCTION:

The aim was to evaluate two biomarker scores trained to identify comorbidity burden in the prediction of specified chronic morbidities, and mortality in the general population.

METHODS:

Cardiovascular biomarkers were measured in the cardiovascular cohort of the Malmö Diet and Cancer Study. A score of 19 biomarkers associated with Charlson Comorbidity Index (CCI) was created (BSMDC). Individuals with CCI diagnoses and other major comorbidities were excluded. Another score of 11 biomarkers associated with comorbidity burden from a previous study of acute dyspnea was also created (BSADYS). The scores were prospectively evaluated for prediction of mortality, and some chronic diseases, using Cox Proportional Hazards Model.

RESULTS:

Fully adjusted models showed that BSMDC was significantly associated per 1 SD increment of the score with incident COPD, 55%, and congestive heart failure, 32%; and with mortality, 33% cardiovascular, 91% respiratory, 30% cancer, and 45% with all-cause mortality. The BSADYS showed no association with these outcomes, after simultaneous inclusion of both biomarker scores to all the clinical covariates.

CONCLUSION:

BSMDC shows strong prediction of morbidity and mortality in individuals free from comorbidities at baseline, and the results suggest that healthy individuals with high level of BSMDC would benefit from intense preventive actions.
A score of 19 biomarkers associated with Charlson Comorbidity Index was created, the Biomarker Score of Malmö Diet and Cancer study (BSMDC).The created BSMDC index was associated with both incident COPD, and incident CHF.BSMDC was also associated with cardiovascular mortality, respiratory mortality, cancer mortality and with all-cause mortality.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Límite: Humans Idioma: En Revista: Biomarkers Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Límite: Humans Idioma: En Revista: Biomarkers Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido