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Secondary Metabolites of Biscogniauxia: Distribution, Chemical Diversity, Bioactivity, and Implications of the Occurrence.
Purbaya, Sari; Harneti, Desi; Safriansyah, Wahyu; Wulandari, Asri Peni; Mulyani, Yeni; Supratman, Unang.
Afiliación
  • Purbaya S; Department of Chemistry, Faculty of Science and Informatics, Universitas Jenderal Achmad Yani, Cimahi 40531, Indonesia.
  • Harneti D; Departments of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Safriansyah W; Departments of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Rahmawati; Departments of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Wulandari AP; Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Mulyani Y; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Supratman U; Departments of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
Toxins (Basel) ; 15(12)2023 12 06.
Article en En | MEDLINE | ID: mdl-38133190
ABSTRACT
The genus Biscogniauxia, a member of the family Xylariaceae, is distributed worldwide with more than 50 recognized taxa. Biscogniauxia species is known as a plant pathogen, typically acting as a parasite on tree bark, although certain members of this genus also function as endophytic microorganisms. Biscogniauxia endophytic strain has received attention in many cases, which includes constituent research leading to the discovery of various bioactive secondary metabolites. Currently, there are a total of 115 chemical compounds belonging to the class of secondary metabolites, and among these compounds, fatty acids have been identified. In addition, the strong pharmacological agents of this genus are (3aS,4aR,8aS,9aR)-3a-hydroxy-8a-methyl-3,5-dimethylenedecahydronaphto [2,3-b]furan-2(3H)-one (HDFO) (antifungal), biscopyran (phytotoxic activity), reticulol (antioxidant), biscogniazaphilone A and B (antimycobacterial), and biscogniauxone (Enzyme GSK3 inhibitor). This comprehensive research contributes significantly to the potential discovery of novel drugs produced by Biscogniauxia and holds promise for future development. Importantly, it represents the first-ever review of natural products originating from the Biscogniauxia genus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucógeno Sintasa Quinasa 3 / Hongos Idioma: En Revista: Toxins (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Suiza
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucógeno Sintasa Quinasa 3 / Hongos Idioma: En Revista: Toxins (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Suiza