Synthesis of Boronic Esters from Organometallic Reagents and Bis(pinacolato)diboron.
Chem Asian J
; 19(4): e202300911, 2024 Feb 16.
Article
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| MEDLINE
| ID: mdl-38131458
ABSTRACT
Synthesis of alkyl, aryl, and vinyl boronic esters carrying various chiral and achiral diol-protecting groups were synthesized starting from the corresponding alkyl, aryl, and vinyl lithium or Grignard reagents. Good to excellent yields were obtained for a large range of substrates. The reaction can be conducted in a gram scale to obtain the product over 80 % yield. This approach provides direct access to neopentyl, pinene, and other boronic esters that are difficult to achieve. Using trimethoxyborane or 2-isopropoxy pinacolboronic ester. Detailed mechanistic studies have been conducted to understand the mechanism behind the formation of boronic ester starting from organometallic reagents.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Chem Asian J
Año:
2024
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Alemania