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Decreased circulating transforming growth factor-beta (TGF-ß) and kidney TGF-ß immunoreactivity predict renal disease in cats with naturally occurring chronic kidney disease.
Piyarungsri, Kakanang; Chuammitri, Phongsakorn; Pringproa, Kidsadagon; Pila, Pattiya; Srivorakul, Saralee; Sornpet, Benjaporn; Pusoonthornthum, Rosama.
Afiliación
  • Piyarungsri K; Department of Companion Animal and Wildlife Clinic, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
  • Chuammitri P; Research Center of Producing and Development of Products and Innovations for Animal Health and Production, Chiang Mai University, Chiang Mai, Thailand.
  • Pringproa K; Research Center of Producing and Development of Products and Innovations for Animal Health and Production, Chiang Mai University, Chiang Mai, Thailand.
  • Pila P; Department of Veterinary Bioscience and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
  • Srivorakul S; Department of Veterinary Bioscience and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
  • Sornpet B; Small Animal Hospital, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
  • Pusoonthornthum R; Veterinary Diagnostic Laboratory, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
J Feline Med Surg ; 25(12): 1098612X231208937, 2023 12.
Article en En | MEDLINE | ID: mdl-38131312
ABSTRACT

OBJECTIVES:

The aim of the present study was to compare the circulating transforming growth factor-beta (TGF-ß) of clinically normal age-matched and naturally occurring chronic kidney disease (CKD) cats and to determine the correlation between the TGF-ß expression and histopathological changes in cats with CKD.

METHODS:

A total of 11 clinically normal age-matched and 27 cats with naturally occurring CKD were included in this study. Circulating TGF-ß was quantified by immunoassays. Kaplan-Meier analysis was used to calculate the association between survival time and the concentration of circulating TGF-ß. A general linear model was used to compare the circulating TGF-ß between groups. Immunohistochemical analyses revealed TGF-ß expression in renal tissues from cats with CKD that died during the study (n = 7) and in available archived renal tissue specimens taken at necropsy from cats that had previous CKD with renal lesions (n = 10). Correlations of the TGF-ß expression and clinical parameters (n = 7) and histopathological changes (n = 17) were analysed using Spearman's rank correlation.

RESULTS:

The median survival time of cats with a lower concentration of circulating TGF-ß was shorter than that of cats with a higher concentration. The area under the curve of circulating TGF-ß for predicting CKD was 0.781, indicating good differentiation. The study indicated a significant difference in circulating TGF-ß concentrations between clinically normal cats and those with CKD and demonstrated that TGF-ß expression is correlated with tubular atrophy. CONCLUSIONS AND RELEVANCE The study findings suggest that decreased serum TGF-ß and tubular atrophy with TGF-ß immunoreactivity may be significant in cats with CKD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Gatos / Insuficiencia Renal Crónica Límite: Animals Idioma: En Revista: J Feline Med Surg Asunto de la revista: MEDICINA VETERINARIA Año: 2023 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Gatos / Insuficiencia Renal Crónica Límite: Animals Idioma: En Revista: J Feline Med Surg Asunto de la revista: MEDICINA VETERINARIA Año: 2023 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido