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Relevance of NAT2 genotype and clinical factors to risk for antituberculosis drug-induced liver injury.
Cheng, Fang; Qiu, Chao-Chao; Jiang, Xian-Gao; Wu, Te; Zhang, Qiang; Chen, Xin; Zheng, Shi-Lin; Liu, Sai-Duo; Ye, Xin-Chun; Shi, Ji-Chan.
Afiliación
  • Cheng F; Department of Infectious Disease of Wenzhou Central Hospital, Wenzhou Central Hospital,The Dingli Clinical College of Wenzhou Medical University,Wenzhou, 325000, China.
  • Qiu CC; Department of Infectious Disease of Wenzhou Central Hospital, Wenzhou Central Hospital,The Dingli Clinical College of Wenzhou Medical University,Wenzhou, 325000, China.
  • Jiang XG; Department of Infectious Disease of Wenzhou Central Hospital, Wenzhou Central Hospital,The Dingli Clinical College of Wenzhou Medical University,Wenzhou, 325000, China.
  • Wu T; Department of Infectious Disease of Wenzhou Central Hospital, Wenzhou Central Hospital,The Dingli Clinical College of Wenzhou Medical University,Wenzhou, 325000, China.
  • Zhang Q; Department of Infectious Disease of Wenzhou Central Hospital, Wenzhou Central Hospital,The Dingli Clinical College of Wenzhou Medical University,Wenzhou, 325000, China.
  • Chen X; Department of Infectious Disease of Wenzhou Central Hospital, Wenzhou Central Hospital,The Dingli Clinical College of Wenzhou Medical University,Wenzhou, 325000, China.
  • Zheng SL; Department of Infectious Disease of Wenzhou Central Hospital, Wenzhou Central Hospital,The Dingli Clinical College of Wenzhou Medical University,Wenzhou, 325000, China.
  • Liu SD; Department of Infectious Disease of Wenzhou Central Hospital, Wenzhou Central Hospital,The Dingli Clinical College of Wenzhou Medical University,Wenzhou, 325000, China.
  • Ye XC; Department of Infectious Disease of Wenzhou Central Hospital, Wenzhou Central Hospital,The Dingli Clinical College of Wenzhou Medical University,Wenzhou, 325000, China.
  • Shi JC; Department of Infectious Disease of Wenzhou Central Hospital, Wenzhou Central Hospital,The Dingli Clinical College of Wenzhou Medical University,Wenzhou, 325000, China.
Pharmacogenomics ; 25(1): 21-28, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38131213
ABSTRACT
The study analyzes the risk factors associated with antituberculosis drug-induced liver injury (ATB-DILI), and the relationship between ATB-DILI and NAT2 gene polymorphisms. Out of the 324 included patients, 57 (17.59%) developed ATB-DILI. Age, history of liver disease, alcohol consumption and timing of antituberculosis (ATB) treatment were independent risk factors for ATB-DILI in the patients with tuberculosis (TB; p < 0.05). There was a significant difference in the distribution of NAT2 metabolic phenotypes between the study group and the control group (p < 0.05). The ATB drug treatment for pulmonary TB can cause a high incidence of ATB-DILI. Age, history of liver disease, alcohol consumption and timing of ATB treatment are independent risk factors for ATB-DILI in patients with TB.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arilamina N-Acetiltransferasa / Tuberculosis / Enfermedad Hepática Inducida por Sustancias y Drogas Límite: Humans Idioma: En Revista: Pharmacogenomics Asunto de la revista: FARMACOLOGIA / GENETICA MEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arilamina N-Acetiltransferasa / Tuberculosis / Enfermedad Hepática Inducida por Sustancias y Drogas Límite: Humans Idioma: En Revista: Pharmacogenomics Asunto de la revista: FARMACOLOGIA / GENETICA MEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido