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Comparison of Patterns of Structural Progression in Primary Open Angle Glaucoma and Pseudoexfoliation Glaucoma.
Wy, Seoyoung; Lee, Yun Jeong; Sun, Sukkyu; Bak, Eunoo; Kim, Young Kook; Park, Ki Ho; Kim, Hee Chan; Jeoung, Jin Wook.
Afiliación
  • Wy S; Hangil Eye Hospital, Incheon.
  • Lee YJ; Department of Ophthalmology, Chungnam National University Hospital, Daejeon.
  • Sun S; Department of Ophthalmology, Seoul National University College of Medicine, Seoul.
  • Bak E; Biomedical Research Institute, Seoul National University Hospital, Seoul.
  • Kim YK; Department of Ophthalmology, Seoul National University College of Medicine, Seoul.
  • Park KH; Department of Ophthalmology, Uijeongbu Eulji Medical Center, Uijeongbu.
  • Kim HC; Department of Ophthalmology, Seoul National University College of Medicine, Seoul.
  • Jeoung JW; Department of Ophthalmology, Seoul National University Hospital, Seoul.
J Glaucoma ; 33(3): 155-161, 2024 03 01.
Article en En | MEDLINE | ID: mdl-38129949
ABSTRACT
PRCIS Primary open angle glaucoma and pseudoexfoliation glaucoma showed different progression patterns of the retinal nerve fiber layer and ganglion cell-inner plexiform layer thinning in OCT-guided progression analysis.

PURPOSE:

To compare the patterns of progression of retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thinning by guided progression analysis (GPA) of optical coherence tomography (OCT) in primary open angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG). MATERIALS AND

METHODS:

The progression of RNFL and GCIPL thinning was assessed by the GPA of Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA). By overlaying the acquired images of the RNFL and GCIPL thickness-change maps, the topographic patterns of progressive RNFL and GCIPL thinning were evaluated. The rates of progression of RNFL and GCIPL thinning were analyzed and compared between patients with POAG and those with PXG.

RESULTS:

Of the 248 eyes of 248 patients with POAG (175 eyes of 175 patients) or PXG (73 eyes of 73 patients) enrolled, 156 POAG eyes and 48 PXG eyes were included. Progressive RNFL thinning was significantly more common in PXG than in POAG ( P =0.005). According to the RNFL progression-frequency maps, progression appeared mainly in the superotemporal and inferotemporal areas in POAG, whereas it had invaded more into the temporal area in PXG. According to the GCIPL maps, progression was most common in the inferotemporal area in both POAG and PXG. The average progression rate of GCIPL thinning was faster in PXG than in POAG ( P =0.013), and when analyzed in 2 halves (superior/inferior), the progression rate of the inferior half was faster in PXG than in POAG ( P =0.011).

CONCLUSIONS:

OCT GPA showed progression patterns of RNFL and GCIPL thinning in POAG and PXG. Understanding the specific patterns of progressive RNFL and GCIPL thinning according to glaucoma type may prove helpful to glaucoma-patient treatment and monitoring.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glaucoma / Glaucoma de Ángulo Abierto / Síndrome de Exfoliación Límite: Humans Idioma: En Revista: J Glaucoma Asunto de la revista: OFTALMOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glaucoma / Glaucoma de Ángulo Abierto / Síndrome de Exfoliación Límite: Humans Idioma: En Revista: J Glaucoma Asunto de la revista: OFTALMOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos