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Precision nephrotoxicity testing using 3D in vitro models.
Yu, Pengfei; Zhu, Hainan; Bosholm, Carol Christine; Beiner, Daniella; Duan, Zhongping; Shetty, Avinash K; Mou, Steve S; Kramer, Philip Adam; Barroso, Luis F; Liu, Hongbing; Cheng, Kun; Ihnat, Michael; Gorris, Matthew A; Aloi, Joseph A; Woldemichael, Jobira A; Bleyer, Anthony; Zhang, Yuanyuan.
Afiliación
  • Yu P; Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
  • Zhu H; The Fourth Department of Liver Disease, Beijing You An Hospital, Capital Medical University, Beijing, China.
  • Bosholm CC; Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
  • Beiner D; Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
  • Duan Z; Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
  • Shetty AK; The Fourth Department of Liver Disease, Beijing You An Hospital, Capital Medical University, Beijing, China.
  • Mou SS; Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
  • Kramer PA; Department of Anesthesiology and Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
  • Barroso LF; Department of Internal Medicine, Section on Gerontology and Geriatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
  • Liu H; Internal Medicine/Infectious Diseases, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
  • Cheng K; Department of Pediatrics and The Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, Tulane Avenue, New Orleans, LA, USA.
  • Ihnat M; Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO, 64108, USA.
  • Gorris MA; Department of Pharmaceutical Sciences, University of Oklahoma College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  • Aloi JA; Division of Endocrinology and Metabolism at Wake Forest Baptist Health, Winston-Salem, NC, USA.
  • Woldemichael JA; Division of Endocrinology and Metabolism at Wake Forest Baptist Health, Winston-Salem, NC, USA.
  • Bleyer A; Division of Nephrology, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
  • Zhang Y; Division of Nephrology, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Cell Biosci ; 13(1): 231, 2023 Dec 21.
Article en En | MEDLINE | ID: mdl-38129901
ABSTRACT
Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of which lack the complexity and functionality of the human kidney. 3D in vitro models are created by culturing human primary kidney cells derived from urine in a 3D microenvironment that mimics the fluid shear stresses of the kidney. Thus, 3D in vitro models provide more accurate and reliable predictions of human nephrotoxicity compared to existing 2D models. In this review, we focus on precision nephrotoxicity testing using 3D in vitro models with human autologous urine-derived kidney cells as a promising approach for evaluating drug safety.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cell Biosci Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cell Biosci Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido