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Prognostic utility and characterization of left ventricular hypertrophy using global thickness.
Lundin, Magnus; Heiberg, Einar; Nordlund, David; Gyllenhammar, Tom; Steding-Ehrenborg, Katarina; Engblom, Henrik; Carlsson, Marcus; Atar, Dan; van der Pals, Jesper; Erlinge, David; Borgquist, Rasmus; Khoshnood, Ardavan; Ekelund, Ulf; Nickander, Jannike; Themudo, Raquel; Nordin, Sabrina; Kozor, Rebecca; Bhuva, Anish N; Moon, James C; Maret, Eva; Caidahl, Kenneth; Sigfridsson, Andreas; Sörensson, Peder; Schelbert, Erik B; Arheden, Håkan; Ugander, Martin.
Afiliación
  • Lundin M; Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institutet, Stockholm, Sweden.
  • Heiberg E; Department of Clinical Sciences Lund, Clinical Physiology, Lund University, Skåne University Hospital, Lund, Sweden.
  • Nordlund D; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.
  • Gyllenhammar T; Department of Clinical Sciences Lund, Clinical Physiology, Lund University, Skåne University Hospital, Lund, Sweden.
  • Steding-Ehrenborg K; Department of Clinical Sciences Lund, Clinical Physiology, Lund University, Skåne University Hospital, Lund, Sweden.
  • Engblom H; Department of Clinical Sciences Lund, Clinical Physiology, Lund University, Skåne University Hospital, Lund, Sweden.
  • Carlsson M; Department of Health Sciences, Physiotherapy, Lund University, Lund, Sweden.
  • Atar D; Department of Clinical Sciences Lund, Clinical Physiology, Lund University, Skåne University Hospital, Lund, Sweden.
  • van der Pals J; Department of Clinical Sciences Lund, Clinical Physiology, Lund University, Skåne University Hospital, Lund, Sweden.
  • Erlinge D; Department of Cardiology, and Institute of Clinical Medicine, Oslo University Hospital Ulleval, University of Oslo, Oslo, Norway.
  • Borgquist R; Arrhythmia Clinic, Skåne University Hospital, and Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
  • Khoshnood A; Department of Clinical Sciences, Cardiology, Lund University, Skåne University Hospital, Lund, Sweden.
  • Ekelund U; Arrhythmia Clinic, Skåne University Hospital, and Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
  • Nickander J; Department of Clinical Sciences, Emergency and Internal Medicine, Lund University, Skåne University Hospital, Lund, Sweden.
  • Themudo R; Department of Clinical Sciences, Emergency and Internal Medicine, Lund University, Skåne University Hospital, Lund, Sweden.
  • Nordin S; Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institutet, Stockholm, Sweden.
  • Kozor R; Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institutet, Stockholm, Sweden.
  • Bhuva AN; Institute of Cardiovascular Science, University College London, London, UK.
  • Moon JC; Kolling Institute, Royal North Shore Hospital, and University of Sydney, Sydney, Australia.
  • Maret E; Institute of Cardiovascular Science, University College London, London, UK.
  • Caidahl K; Department of Cardiology, Barts Heart Centre, London, UK.
  • Sigfridsson A; Institute of Cardiovascular Science, University College London, London, UK.
  • Sörensson P; Department of Cardiology, Barts Heart Centre, London, UK.
  • Schelbert EB; Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institutet, Stockholm, Sweden.
  • Arheden H; Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institutet, Stockholm, Sweden.
  • Ugander M; Institute of Medicine, University of Gothenburg and Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Sci Rep ; 13(1): 22806, 2023 12 20.
Article en En | MEDLINE | ID: mdl-38129418
ABSTRACT
Cardiovascular magnetic resonance (CMR) can accurately measure left ventricular (LV) mass, and several measures related to LV wall thickness exist. We hypothesized that prognosis can be used to select an optimal measure of wall thickness for characterizing LV hypertrophy. Subjects having undergone CMR were studied (cardiac patients, n = 2543; healthy volunteers, n = 100). A new measure, global wall thickness (GT, GTI if indexed to body surface area) was accurately calculated from LV mass and end-diastolic volume. Among patients with follow-up (n = 1575, median follow-up 5.4 years), the most predictive measure of death or hospitalization for heart failure was LV mass index (LVMI) (hazard ratio (HR)[95% confidence interval] 1.16[1.12-1.20], p < 0.001), followed by GTI (HR 1.14[1.09-1.19], p < 0.001). Among patients with normal findings (n = 326, median follow-up 5.8 years), the most predictive measure was GT (HR 1.62[1.35-1.94], p < 0.001). GT and LVMI could characterize patients as having a normal LV mass and wall thickness, concentric remodeling, concentric hypertrophy, or eccentric hypertrophy, and the three abnormal groups had worse prognosis than the normal group (p < 0.05 for all). LV mass is highly prognostic when mass is elevated, but GT is easily and accurately calculated, and adds value and discrimination amongst those with normal LV mass (early disease).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertrofia Ventricular Izquierda / Insuficiencia Cardíaca Límite: Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertrofia Ventricular Izquierda / Insuficiencia Cardíaca Límite: Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido