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Low-load blood flow restriction strength training in patients with COPD: a randomised single-blind pilot study.
Kohlbrenner, Dario; Kuhn, Manuel; Manettas, Anastasios; Aregger, Céline; Peterer, Matthias; Greco, Nicola; Sievi, Noriane A; Clarenbach, Christian.
Afiliación
  • Kohlbrenner D; Faculty of Medicine, University of Zurich, Zurich, Switzerland dario.kohlbrenner@usz.ch.
  • Kuhn M; Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
  • Manettas A; Faculty of Medicine, University of Zurich, Zurich, Switzerland.
  • Aregger C; Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
  • Peterer M; Physiotherapy Occupational Therapy, University Hospital Zurich, Zurich, Switzerland.
  • Greco N; Biomechanics and Ergonomics, ErgoMech Laboratory, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
  • Sievi NA; Physiotherapy Occupational Therapy, University Hospital Zurich, Zurich, Switzerland.
  • Clarenbach C; Physiotherapy Occupational Therapy, University Hospital Zurich, Zurich, Switzerland.
Thorax ; 79(4): 340-348, 2024 Mar 15.
Article en En | MEDLINE | ID: mdl-38129116
ABSTRACT

OBJECTIVE:

The objective of this study is to compare the effectiveness of lower limb low-load blood flow restriction training (LL-BFRT) with high-load strength training (HL-ST) as part of an outpatient pulmonary rehabilitation programme on leg strength in patients with chronic obstructive pulmonary disease (COPD).

METHODS:

Participants were randomised to LL-BFRT or HL-ST (24 sessions). LL-BFRT was done at 30% 1-repetition maximum (1-RM) with 70% arterial occlusion pressure. HL-ST was done at 70% 1-RM. Primary outcome was isometric strength of knee extensors and flexors. Secondary outcomes were 1-RM, functional exercise capacity, physical activity, symptom burden and health-related quality of life. Perceptions of dyspnoea and leg fatigue were recorded after every exercise. We compared groups with t-tests.

RESULTS:

We included 30 participants (13 women, 17 men, 64 (9) years, forced expiratory volume in 1 s 47 (18)% pred.), 24 completed the study. Isometric knee extensor strength improved to a clinically relevant degree in both legs in both groups (LL-BFRT right leg 9 (20) Nm, left leg 10 (18) Nm; HL-ST right leg 15 (26) Nm, left leg 16 (30) Nm, data are mean (SD)), without statistically significant or clinically relevant between-group differences (right leg mean difference= -6.4, 95% CI= -13.20 to 25.92 Nm, left leg mean difference= -5.6, 95% CI= -15.44 to 26.55 Nm). 1 min sit-to-stand test performance improved to a clinically relevant degree only in the LL-BFRT group (4 (4) vs 1 (5) repetitions). Interestingly, physical activity improved to a clinically relevant degree only in the LL-BFRT group (1506 (2441) vs -182 (1971) steps/day). LL-BFRT lowered perceived in-exercise dyspnoea and increased leg fatigue compared with HL-ST in the initial 12 trainings.

CONCLUSION:

In patients with stable COPD undergoing outpatient pulmonary rehabilitation, LL-BFRT was not superior to HL-ST in improving leg strength. LL-BFRT led to similar strength gains as HL-ST while reducing perceptions of dyspnoea in the initial training phase. TRIAL REGISTRATION NUMBER NCT04151771.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Pulmonar Obstructiva Crónica / Entrenamiento de Fuerza Límite: Female / Humans / Male Idioma: En Revista: Thorax Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Pulmonar Obstructiva Crónica / Entrenamiento de Fuerza Límite: Female / Humans / Male Idioma: En Revista: Thorax Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido