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Functional assessment of brain development in fetuses that subsequently deliver very preterm: An MRI pilot study.
Story, Lisa; Uus, Alena; Hall, Megan; Payette, Kelly; Bakalis, Spyros; Arichi, Tomoki; Shennan, Andrew; Rutherford, Mary; Hutter, Jana.
Afiliación
  • Story L; Department of Women's and Children's Health, King's College London, St Thomas' Hospital London, London, UK.
  • Uus A; Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital London, London, UK.
  • Hall M; Fetal Medicine Unit, St Thomas' Hospital London, London, UK.
  • Payette K; Department of Women's and Children's Health, King's College London, St Thomas' Hospital London, London, UK.
  • Bakalis S; Department of Women's and Children's Health, King's College London, St Thomas' Hospital London, London, UK.
  • Arichi T; Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital London, London, UK.
  • Shennan A; Department of Women's and Children's Health, King's College London, St Thomas' Hospital London, London, UK.
  • Rutherford M; Fetal Medicine Unit, St Thomas' Hospital London, London, UK.
  • Hutter J; Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital London, London, UK.
Prenat Diagn ; 44(1): 49-56, 2024 01.
Article en En | MEDLINE | ID: mdl-38126921
ABSTRACT

OBJECTIVES:

To evaluate changes occurring in the fetal brain prior to very preterm delivery using MRI T2* relaxometry, an indirect assessment of tissue perfusion.

METHOD:

Fetuses that subsequently delivered spontaneously <32 weeks gestation and a control cohort were identified from pre-existing datasets. Participants had undergone a 3T MRI assessment including T2* relaxometry of the fetal brain using a 2D multi-slice gradient echo single shot echo planar imaging sequence. T2* maps were generated, supratentorial brain tissue was manually segmented and mean T2* values were generated. Groups were compared using quadratic regression.

RESULTS:

Twenty five fetuses that subsequently delivered <32 weeks and 67 that delivered at term were included. Mean gestation at MRI was 24.5 weeks (SD 3.3) and 25.4 weeks (SD 3.1) and gestation at delivery 25.5 weeks (SD 3.4) and 39.7 weeks (SD 1.2) in the preterm and term cohorts respectively. Brain mean T2* values were significantly lower in fetuses that subsequently delivered before 32 weeks gestation (p < 0.001).

CONCLUSION:

Alterations in brain maturation appear to occur prior to preterm delivery. Further work is required to explore these associations, but these findings suggest a potential window for therapeutic neuroprotective agents in fetuses at high risk of preterm delivery in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nacimiento Prematuro Límite: Female / Humans / Newborn Idioma: En Revista: Prenat Diagn Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nacimiento Prematuro Límite: Female / Humans / Newborn Idioma: En Revista: Prenat Diagn Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido