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Clinical outcomes and prognostic factors of head and neck squamous cell carcinoma: a ten-year follow-up study.
Dias, Kelly Bienk; Hildebrand, Laura Campos; Carvalho, Ana Luísa Homem de; Ferri, Camila Alves; Nör, Jacques Eduardo; Cerski, Carlos Thadeu Schmidt; Visioli, Fernanda; Oliveira, Márcia Gaiger; Rados, Pantelis Varvaki.
Afiliación
  • Dias KB; Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry , Pathology Department , Porto Alegre , RS , Brazil.
  • Hildebrand LC; Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry , Pathology Department , Porto Alegre , RS , Brazil.
  • Carvalho ALH; Pathology Department , School of Dentistry , Pontifícia Universidade Católica do Grande do Sul , Porto Alegre , Rio Grande do Sul , Brazil.
  • Ferri CA; Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry , Pathology Department , Porto Alegre , RS , Brazil.
  • Nör JE; University of Michigan , School of Dentistry , Cariology Department, Restorative Sciences, and Endodontics , Ann Arbor , MI , USA.
  • Cerski CTS; Universidade Federal do Rio Grande do Sul - UFRGS, Hospital de Clinícas de Porto Alegre , Porto Alegre , RS , Brazil.
  • Visioli F; Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry , Pathology Department , Porto Alegre , RS , Brazil.
  • Oliveira MG; Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry , Pathology Department , Porto Alegre , RS , Brazil.
  • Rados PV; Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry , Pathology Department , Porto Alegre , RS , Brazil.
Braz Oral Res ; 37: e128, 2023.
Article en En | MEDLINE | ID: mdl-38126472
ABSTRACT
Traditional guidelines for determining the prognosis of patients with head and neck squamous cell carcinoma (HNSCC) are used to make therapeutic decisions. However, only 50% of the patients had lived for more than five years. The present study aimed to analyze the correlation of traditional prognostic factors such as tumor size, histological grading, regional metastases, and treatment with the survival of patients with HNSCC. A total of 78 patients diagnosed with HNSCC were followed up for 10 years after diagnosis and treatment. The health status of the patients was tracked at four time points, and according to the evolution of the patients and their final clinical status, we performed a prognostic analysis based on the clinical outcomes observed during the follow-up period. The final study cohort comprised 50 patients. Most patients had tumors < 4 cm in size (64%) and no regional metastases (64%); no patients had distant metastases at the time of diagnosis. Most individuals had tumors with good (48%) and moderate (46%) degrees of malignancy. At the end of the follow-up period, only 14% of the patients were discharged, 42% died of the tumor, and 44% remained under observation owing to the presence of a potentially malignant disorder, relapse, or metastases. This analysis showed that traditional prognostic factors were not accurate in detecting subclinical changes or predicting the clinical evolution of patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Límite: Humans Idioma: En Revista: Braz Oral Res Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Límite: Humans Idioma: En Revista: Braz Oral Res Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil