Your browser doesn't support javascript.
loading
New antipsychotic prescription and recurrent infections among adult sepsis survivors: A population-based cohort study.
Ferraris, Augusto; Szmulewicz, Alejandro G; Burry, Lisa; Phipps, Amanda; Wunsch, Hannah; Scales, Damon C; Angriman, Federico.
Afiliación
  • Ferraris A; Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
  • Szmulewicz AG; Laboratory of Applied Statistics in Health Sciences, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
  • Burry L; Epidemiology Department, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
  • Phipps A; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
  • Wunsch H; Mount Sinai Hospital, Sinai Health System, Toronto, Ontario, Canada.
  • Scales DC; Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
  • Angriman F; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Pharmacoepidemiol Drug Saf ; 33(2): e5747, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38126218
ABSTRACT

PURPOSE:

Antipsychotic agents, which may increase the risk of infection through dopaminergic dysregulation, are prescribed to a fraction of patients following critical illness. We compared the rate of recurrent sepsis among patients who filled a prescription for antipsychotics with high- or low-D2 affinity.

METHODS:

Population-based cohort with active comparator design. We included sepsis survivors older than 65 years with intensive care unit admission and new prescription of antipsychotics in Ontario 2008-2019. The primary outcome were recurrent sepsis episodes within 1 year of follow-up. Patients who filled a prescription within 30 days of hospital discharge for high-D2 affinity antipsychotics (e.g., haloperidol) were compared with patients who filled a prescription within 30 days of hospital discharge for low-D2 affinity antipsychotics (e.g., quetiapine). Multivariable zero-inflated Poisson regression models with robust standard errors adjusting for confounding at baseline were used to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI).

RESULTS:

Overall, 1879 patients filled a prescription for a high-D2, and 1446 patients filled a prescription for a low-D2 affinity antipsychotic. Patients who filled a prescription for a high-D2 affinity antipsychotic did not present a higher rate of recurrent sepsis during 1 year of follow-up, compared with patients who filled a prescription for a low-D2 affinity antipsychotic (IRR 1.12; 95% CI 0.94, 1.35).

CONCLUSIONS:

We did not find conclusive evidence of a higher rate of recurrent sepsis associated with the prescription of high-D2 affinity antipsychotics (compared with low-D2 affinity antipsychotics) by 1 year of follow-up in adult sepsis survivors with intensive care unit admission.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antipsicóticos / Sepsis Límite: Adult / Humans Idioma: En Revista: Pharmacoepidemiol Drug Saf Asunto de la revista: EPIDEMIOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antipsicóticos / Sepsis Límite: Adult / Humans Idioma: En Revista: Pharmacoepidemiol Drug Saf Asunto de la revista: EPIDEMIOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido