Your browser doesn't support javascript.
loading
Cross-sectional study of the associations between circulating vitamin D concentrations and insulin resistance in children aged 9-10 years of South Asian, black African Caribbean and white European origins.
Donin, Angela; Nightingale, Claire M; Sattar, Naveed; Fraser, William D; Owen, Chris G; Cook, Derek G; Whincup, Peter H.
Afiliación
  • Donin A; Population Health Research Institute, St George's University of London, London, UK adonin@sgul.ac.uk.
  • Nightingale CM; Population Health Research Institute, St George's University of London, London, UK.
  • Sattar N; Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.
  • Fraser WD; Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
  • Owen CG; Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
  • Cook DG; Population Health Research Institute, St George's University of London, London, UK.
  • Whincup PH; Population Health Research Institute, St George's University of London, London, UK.
J Epidemiol Community Health ; 2023 Dec 11.
Article en En | MEDLINE | ID: mdl-38123968
ABSTRACT

BACKGROUND:

Lower circulating vitamin D 25-hydroxyvitamin D (25(OH)D) concentrations are associated with higher type 2 diabetes risk in adults, although causality remains uncertain. However, associations between 25(OH)D and type 2 diabetes risk markers in children have been little studied, particularly in ethnic minority populations. We examined whether 25(OH)D concentrations were associated with insulin resistance in children and whether lower 25(OH)D concentrations in South Asians and black African Caribbeans could contribute to their higher insulin resistance.

METHODS:

Cross-sectional study of 4650 UK primary school children aged 9-10 years of predominantly South Asian, black African Caribbean and white European ethnicity. Children had fasting blood measurements of circulating 25(OH)D metabolite concentrations, insulin and glucose.

RESULTS:

Lower 25(OH)D concentrations were observed in girls, South Asians and black African Caribbeans. In analyses adjusted for age, sex, month, ethnic group and school, circulating 25(OH)D was inversely associated with fasting insulin (-0.38%, 95% CI -0.49% to -0.27%), homoeostasis model assessment (HOMA) insulin resistance (-0.39%, 95% CI -0.50% to -0.28%) and fasting glucose (-0.03%, 95% CI -0.05% to -0.02%) per nmol/L increase in 25(OH)D; associations did not differ between ethnic groups. Ethnic differences in fasting insulin and HOMA insulin resistance (higher among South Asian and black African Caribbeans) were reduced by >40% after adjustment for circulating 25(OH)D concentrations.

CONCLUSION:

Circulating vitamin D was inversely associated with insulin resistance in all ethnic groups; higher insulin resistance in South Asian and black African children were partly explained by their lower vitamin D levels. Whether vitamin D supplementation can reduce emerging type 2 diabetes risk needs further evaluation.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Epidemiol Community Health Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Epidemiol Community Health Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido