A Neutral Flavin-Triphenylamine Probe for Mitochondrial Bioimaging under Different Microenvironments.

Agrawal, Harsha Gopal; Giri, Pravin Shankar; Meena, Poonam; Rath, Subha Narayan; Mishra, Ashutosh Kumar

Agrawal, Harsha Gopal; Giri, Pravin Shankar; Meena, Poonam; Rath, Subha Narayan; Mishra, Ashutosh Kumar.

Afiliación

Agrawal HG; Department of Chemistry, Indian Institute of Technology, Sangareddy, Hyderabad 502285, Telangana, India.
Giri PS; Department of Biomedical Engineering, Indian Institute of Technology, Sangareddy, Hyderabad502285, Telangana, India.
Meena P; Department of Chemistry, Indian Institute of Technology, Sangareddy, Hyderabad 502285, Telangana, India.
Rath SN; Department of Biomedical Engineering, Indian Institute of Technology, Sangareddy, Hyderabad502285, Telangana, India.
Mishra AK; Department of Chemistry, Indian Institute of Technology, Sangareddy, Hyderabad 502285, Telangana, India.

ACS Med Chem Lett ; 14(12): 1857-1862, 2023 Dec 14.

Article en En | MEDLINE | ID: mdl-38116415

ABSTRACT

ABSTRACT

A bioinspired design built around a neutral flavin-triphenylamine core has been investigated for selective mitochondrial bioimaging capabilities in different microenvironments. Significant advantages with respect to long-term tracking, faster internalization, penetrability within the spheroid structures, and strong emission signal under induced hypoxia conditions have been observed, which could offer an alternative to the existing mitotrackers for hypoxia-related biological events.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos

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